Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8077 | Plantagoside |
| 1. Plantagoside is a potent inhibitor of the Maillard reaction, it also can inhibit the formation of advanced glycation end products in proteins in physiological conditions and inhibit protein cross-linking glycation. 2. Plantagoside has potential therapeutic applications in the prevention of diabetic complications. 3. Plantagoside is a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50 at 5 microM). 4. Plantagoside suppresses antibody response to sheep red blood cells and concanavalin A induced lymphocyte proliferation which was measured by [3H]thymidine incorporation. | |
| BCC7495 | Withaferin A |
| 1. Withaferin A(WFA) has anti-inflammatory, anti-oxidant, immune modulatory, cardioactive, antithrombotic and central nervous system effects. 2. Withaferin A is a potent breast cancer anti-metastatic agent and the anti-metastatic activity of WFA is, at least in part, mediated through its effects on vimentin and vimentin ser56 phosphorylation. 3. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells, it can be exploited as a potent therapeutic agent for the treatment and prevention of cervical cancer without deleterious effects. 4. Withaferin A could act as an anti-fibrotic compound against fibroproliferative diseases, including, but not limited to, cardiac interstitial fibrosis. 5. Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. 6. Withaferin A is a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. | |
| BCN8076 | 26-Deoxyactein |
| 1. 23-epi-26-Deoxyactein can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1. 2. 23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. | |
| BCN8075 | Gossypetin |
| 1. Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects. 2. Gossypetin inhibits bone resorption through down-regulating lysosomal cathepsin K activity and autophagy-related protein induction in actin ring-bearing osteoclasts. 3. Gossypetin ameliorates ionizing radiation-induced oxidative stress in mice liver, it shows radioprotective action against gamma (γ)-radiation-induced oxidative stress. 4. Gossypetin is an inducer of apoptotic and autophagic cell death in LNCaP cells, and provide a new mechanism for its anticancer activity. | |
| BCN8074 | Delta-9-Tetrahydrocannabinol |
| 1. Delta 9-tetrahydrocannabinol(THC) induces dopamine release in the human striatum, this allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia. 2. THC demonstrates an analgesic effect in patients experiencing cancer pain. 3. THC shows neuroprotection against ouabain-induced in vivo excitotoxicity. 4. THC promotes tumor growth by inhibiting antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. 5. THC has antiemetic effect in patients receiving cancer chemotherapy. | |
| BCN8073 | Helenalin |
| 1. Helenalin is a promising experimental cytotoxic agent that possibly points to new strategies to overcome apoptosis resistance attributable to overexpression of antiapoptotic Bcl-2 proteins. 2. Helenalin has anti-inflammatory activity, it inhibits the transcription factor NF-kappaB by directly targeting p65. 3. Helenalin is a new immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses. 4. Helenalin has anti-trypanosomal activity against the African Trypanosoma brucei rhodesiense and American T. cruzi. 5. Helenalin reduces Staphylococcus aureus infection in vitro and in vivo. 6. Helenalin has anticancer activity, it contributes to the induction of autophagy cell death by NF-κB p65 repression. | |
| BCN8071 | Artocarpesin |
| 1. Artocarpesin displays cytotoxic effects at various extent on all the 9 tested cancer cell lines with IC50 values respectively below 106 uM. 2. Artocarpesin shows tyrosinase inhibitory activity. 3. Artocarpesin has interesting antimicrobial potency. 4. Artocarpesin has anti-inflammatory effects, it can suppress the LPS-induced production of nitric oxide (NO) and prostaglandin E 2 (PGE 2) through the down-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) protein expressions. | |
| BCN8070 | Gericudranin E |
| 1. Gericudranin E shows significant hepatoprotective effects with the EC50 value of 39.87+/-0.7 microM. | |
