Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8092 | Pseudolarolide Q2 |
| 1. Pseudolarolide Q exhibits strong antimicrobial activity against Gram-positive Staphylococcus aureus and Candida albicans at the MICs of 6.08 and 24.32 uM. | |
| BCN8091 | Alloalantolactone |
| 1. Alloalantolactone shows activity against M. tuberculosis (32 micrograms/ml). | |
| BCN8087 | Fmoc-L-Beta-Homoproline |
| 1. Orientin-2''-O-p-trans-coumarate can strongly promote 2BS cell proliferation induced by H(2)O(2). | |
| BCN8086 | N-(3-Methoxybenzyl)palmitamide |
|
1. N-(3-Methoxybenzyl)palmitamide can counteract the toxicity produced by Aβ (25-35). 2. N-(3-methoxybenzyl)palmitamide is a promising inhibitor of fatty acid amide hydrolase (FAAH) and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders. |
|
| BCN8085 | Negletein |
| 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. | |
| BCN8083 | Citrusinol |
| 1. Citrusinol exhibits cytotoxic activities against the HepG2 cell. | |
| BCN8082 | Tetramethylkaempferol |
| 1. Tetramethylkaempferol can concentration-dependently enhance the accumulation of triglyceride, a marker of adipogenesis. 2. Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. | |
| BCN8081 | Trimethylapigenin |
| 1. Trimethyapigenin may be a potential candidate for anti-atrial fibrillation, it can significantly inhibit the atrial potassium currents hKv1.5/I(Kur) and I(KACh). 2. Trimethyapigenin has anti-inflammatory activity, it can moderately inhibit production of TNF-α. ,iNOS mRNA and iNOS protein in a dose-dependent manner. | |
