Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8245 | Daidzin 6'-O-malonate |
| 1. Daidzin 6''-O-malonate may have anticancer activity. | |
| BCN8248 | Pendulone |
| 1. Pendulone exhibits good anti-plasmodial activity with the IC50 value of 7.0 ± 0.8 uM. 2. Pendulone displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 1.44 microg/mL). 3. Pendulone shows potent leishmanicidal activity. 4. Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test. | |
| BCN8255 | Tetrahydromagnolol |
| 1. Tetrahydromagnolol can activate cannabinoid (CB) receptors. | |
| BCN8256 | 4',5,6,7-Tetramethoxyflavone |
| 1. 4',5,6,7-Tetramethoxyflavone has a hemostatic effect. | |
| BCN8257 | Micheliolide |
| 1. Micheliolide has potential as a candidate drug for the treatment of diabetic nephropathy, it can effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs). 2. Micheliolide ameliorates liver steatosis by upregulating PPAR-γ expression, thereby inhibiting NF-κB-mediated inflammation and activating AMPK/mTOR-dependent autophagy. 3. Micheliolide may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders. it can suppress LPS-induced neuroinflammatory responses. 4. Micheliolide plays anti-inflammatory and immunomodulatory roles in Mycobacterium tuberculosis-induced immune response by inhibiting NF-κB and NLRP3 inflammasome activation. 5. Micheliolide exerts its antineoplastic effects via inhibition of NF-κB expression and activity, and by generating intracellular reactive oxygen species (ROS). | |
| BCN8258 | Dihydroseselin |
| 1. Dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity. | |
| BCN8274 | Lirinidine |
| 1. (+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells. 2. (-)-Lirinidine shows potent inhibition of melanogenesis. 3. Lirinidine exhibits significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation. | |
| BCN8694 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid |
| 1. 3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ). | |
