Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 1225 - 1232 of 9359 hot products
| Catalog No. | Product Name |
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| BCC5599 | Gap19 |
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Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.
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| BCC5600 | EC 144 |
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High affinity, potent and selective Hsp90 inhibitor (K<sub>i</sub> = 0.2 nM and IC<sub>50</sub> = 1.1 nM). Exhibits selectivity for Hsp90 over Grp94 and TRAP1 (K<sub>i</sub> values are 61 and 255 nM respectively) and has no effect (IC<sub>50</sub> >10 <span class='symbol'>μ</span>M) against a panel of 285 kinases. Degrades Her-2 in MCF-7 breast cancer cells (EC<sub>50</sub> = 14 nM). Blocks tumor growth and induces partial tumor regression in an N87 gastric tumor mouse model. Also inhibits LPS-induced TNF<span class='symbol'>α</span> release in an LPS shock mouse model and suppresses disease development in a rat model of collagen-induced arthritis. Exhibits <20-fold efficacy over BIIB 021 in mice. Orally available and brain penetrant.
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| BCC5601 | CCG 203971 |
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Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, <span class='symbol'>α</span>-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGF<span class='symbol'>β</span>-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition <em>in vivo</em>. Also suppresses PC-3 cell migration in scratch wound assays (IC<sub>50</sub> = 4.2 <span class='symbol'>μ</span>M).
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| BCC5602 | IWP 4 |
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Potent inhibitor of Wnt/<span class='symbol'>β</span>-catenin signaling (IC<sub>50</sub> = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
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| BCC5603 | C34 |
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TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.
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| BCC5604 | ML 240 |
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ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
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| BCC5605 | CE3F4 |
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Noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
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| BCC5606 | CVT 10216 |
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Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.
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