Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN8068 | Shuterin |
| 1. Shuterin displays potent antioxidant activity. | |
| BCN8067 | Cudraflavone B |
| 1. Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. 2. Cudraflavone B may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells. | |
| BCN8066 | Diphyllin |
| 1. Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. 2. Diphyllin has in vitro antileishmanial activity, it exerts a strong specific inhibitory activity (IC50 = 0.2 microM) resulting from the inhibition of parasite internalization within macrophages. 3. Diphyllin has anti-inflammatory activities, it shows 50% inhibition of NO production from peritoneal macrophages. | |
| BCN8063 | Podophyllotoxinone |
| 1. Podophyllotoxinone shows inhibitory activity against L1210 leukemia and KB cells in vitro. | |
| BCN8062 | Magnoloside D |
| 1. Magnoloside D shows moderate cytotoxicity against MGC-803 and HepG2 cells. 2. Magnoloside D shows potent antioxidant capacity. | |
| BCN8057 | Zeylasterone |
| 1. Zeylasterone shows bactericidal activity. | |
| BCN8053 | Nimbolide |
| 1. Nimbolide is a more potent antiproliferative and apoptosis inducing agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer. 2. Nimbolide can sensitize tumor cells to chemotherapeutic agents through interaction with IKK, leading to inhibition of NF-κB-regulated proteins. 3. Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines. 4. Nimbolide attenuates the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes. 5. Nimbolide has antibacterial potential . | |
| BCN8052 | Salannin |
| 1. Salannin inhibits ecdysone 20-monooxygenase (E-20-M) activity in a dose-dependent fashion. 2. Salannin has antifeedant and insect growth-regulating activities . 3. Salannin has anti-inflammatory activity,it exerts moderate inhibition (IC(50) values of 410-471 mol ratio/32 pmol TPA) of TPA-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. | |
