BRD73954CAS# 1440209-96-0 |
- CI994 (Tacedinaline)
Catalog No.:BCC2159
CAS No.:112522-64-2
- Romidepsin (FK228, depsipeptide)
Catalog No.:BCC3597
CAS No.:128517-07-7
- Tubastatin A HCl
Catalog No.:BCC3877
CAS No.:1310693-92-5
- M344
Catalog No.:BCC2162
CAS No.:251456-60-7
- JNJ-26481585
Catalog No.:BCC2147
CAS No.:875320-29-9
- AR-42 (OSU-HDAC42)
Catalog No.:BCC2161
CAS No.:935881-37-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1440209-96-0 | SDF | Download SDF |
PubChem ID | 71680913 | Appearance | Powder |
Formula | C16H16N2O3 | M.Wt | 284.31 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | DMSO : 25 mg/mL (87.93 mM; Need ultrasonic) | ||
Chemical Name | 3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide | ||
SMILES | C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO | ||
Standard InChIKey | FIHKWEQJEDRIFS-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively. |
BRD73954 Dilution Calculator
BRD73954 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.5173 mL | 17.5864 mL | 35.1729 mL | 70.3457 mL | 87.9322 mL |
5 mM | 0.7035 mL | 3.5173 mL | 7.0346 mL | 14.0691 mL | 17.5864 mL |
10 mM | 0.3517 mL | 1.7586 mL | 3.5173 mL | 7.0346 mL | 8.7932 mL |
50 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL | 1.4069 mL | 1.7586 mL |
100 mM | 0.0352 mL | 0.1759 mL | 0.3517 mL | 0.7035 mL | 0.8793 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
- Sodium Nitroprusside
Catalog No.:BCC4844
CAS No.:14402-89-2
- Sulfapyridine
Catalog No.:BCC4729
CAS No.:144-83-2
- Sulfamethizole
Catalog No.:BCC4856
CAS No.:144-82-1
- Sulfathiazole sodium
Catalog No.:BCC5207
CAS No.:144-74-1
- Zeaxanthin
Catalog No.:BCN2380
CAS No.:144-68-3
- Oxalic acid
Catalog No.:BCN8515
CAS No.:144-62-7
- Sodium bicarbonate
Catalog No.:BCC7584
CAS No.:144-55-8
- Sodium barbital
Catalog No.:BCN2160
CAS No.:144-02-5
- CTX0294885
Catalog No.:BCC6396
CAS No.:1439934-41-4
- Jaceidin triacetate
Catalog No.:BCN6245
CAS No.:14397-69-4
- CB-839
Catalog No.:BCC5493
CAS No.:1439399-58-2
- M40
Catalog No.:BCC7686
CAS No.:143896-17-7
- Piclamilast
Catalog No.:BCC6215
CAS No.:144035-83-6
- 6-O-Syringoylajugol
Catalog No.:BCN6246
CAS No.:144049-72-9
- Febuxostat
Catalog No.:BCC2556
CAS No.:144060-53-7
- Deltarasin
Catalog No.:BCC1524
CAS No.:1440898-61-2
- Deltarasin hydrochloride
Catalog No.:BCC4270
CAS No.:1440898-82-7
- Tarasaponin VII
Catalog No.:BCN2684
CAS No.:144118-18-3
- Fmoc-Asp-OAll
Catalog No.:BCC3086
CAS No.:144120-53-6
- Fmoc-Glu-OAll
Catalog No.:BCC3490
CAS No.:144120-54-7
- Eprosartan Mesylate
Catalog No.:BCC4658
CAS No.:144143-96-4
- Ledipasvir acetone
Catalog No.:BCC4046
CAS No.:1441674-54-9
- Indoxacarb
Catalog No.:BCN2263
CAS No.:144171-61-9
- 1-Acetyl-4-methylpiperazine hydrochloride
Catalog No.:BCC6615
CAS No.:144205-68-5
Discovery of the first histone deacetylase 6/8 dual inhibitors.[Pubmed:23672185]
J Med Chem. 2013 Jun 13;56(11):4816-20.
We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8.