BRD73954CAS# 1440209-96-0 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1440209-96-0 | SDF | Download SDF |
| PubChem ID | 71680913 | Appearance | Powder |
| Formula | C16H16N2O3 | M.Wt | 284.31 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 25 mg/mL (87.93 mM; Need ultrasonic) | ||
| Chemical Name | 3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide | ||
| SMILES | C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO | ||
| Standard InChIKey | FIHKWEQJEDRIFS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively. |
BRD73954 Dilution Calculator
BRD73954 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5173 mL | 17.5864 mL | 35.1729 mL | 70.3457 mL | 87.9322 mL |
| 5 mM | 0.7035 mL | 3.5173 mL | 7.0346 mL | 14.0691 mL | 17.5864 mL |
| 10 mM | 0.3517 mL | 1.7586 mL | 3.5173 mL | 7.0346 mL | 8.7932 mL |
| 50 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL | 1.4069 mL | 1.7586 mL |
| 100 mM | 0.0352 mL | 0.1759 mL | 0.3517 mL | 0.7035 mL | 0.8793 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
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Discovery of the first histone deacetylase 6/8 dual inhibitors.[Pubmed:23672185]
J Med Chem. 2013 Jun 13;56(11):4816-20.
We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong to distinct phylogenetic classes within the HDAC family of enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic acids are readily accommodated upon binding to HDAC6 and, furthermore, are necessary for the potent inhibition of HDAC8.
BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
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