CTX0294885Pan-kinase inhibitor CAS# 1439934-41-4 |
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| Cas No. | 1439934-41-4 | SDF | Download SDF |
| PubChem ID | 71558939 | Appearance | Powder |
| Formula | C22H24ClN7O | M.Wt | 437.93 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (228.35 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[[5-chloro-2-(4-piperazin-1-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide | ||
| SMILES | CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3)N4CCNCC4 | ||
| Standard InChIKey | FCLOIQHNUARDSR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C22H24ClN7O/c1-24-21(31)17-4-2-3-5-19(17)28-20-18(23)14-26-22(29-20)27-15-6-8-16(9-7-15)30-12-10-25-11-13-30/h2-9,14,25H,10-13H2,1H3,(H,24,31)(H2,26,27,28,29) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.
Target: Kinase capture reagent
Use of a quantitative proteomics approach confirmed the selectivity of CTx-0294885-bound beads for kinase enrichment. Large-scale CTx-0294885-based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase-enrichment increased the number of kinase identifications to 261, representing the largest kinome coverage from a single cell line reported to date. Coupling phosphopeptide enrichment with affinity purification using the four inhibitors enabled the identification of 799 high-confidence phosphosites on 183 kinases, ～10% of which were localized to the activation loop, and included previously unreported phosphosites on BMP2K, MELK, HIPK2, and PRKDC. Therefore, CTx-0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies. References: | |||||
CTX0294885 Dilution Calculator
CTX0294885 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2835 mL | 11.4173 mL | 22.8347 mL | 45.6694 mL | 57.0867 mL |
| 5 mM | 0.4567 mL | 2.2835 mL | 4.5669 mL | 9.1339 mL | 11.4173 mL |
| 10 mM | 0.2283 mL | 1.1417 mL | 2.2835 mL | 4.5669 mL | 5.7087 mL |
| 50 mM | 0.0457 mL | 0.2283 mL | 0.4567 mL | 0.9134 mL | 1.1417 mL |
| 100 mM | 0.0228 mL | 0.1142 mL | 0.2283 mL | 0.4567 mL | 0.5709 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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CTx-0294885 is a novel bisanilino pyrimidine. It has inhibitory activity towards a wild range of kinases in vitro. CTx-0294885 is capable of capturing more than half of the expressed kinome in MDA-MB-231 cells. Large-scale CTx-0294885-based affinity purification with LC−MS/MS identifies 235 protein kinases. CTx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. It is further developed into a Sepharose-supported kinase capture reagent. CTx-0294885 is a new tool for analysis of kinome signaling networks. [1]
Reference:
1. Zhang L, Holmes IP, Hochgräfe F et al. Characterization of the novel broad-spectrum
kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based
kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.
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CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.
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