Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6679 | Licoricidin |
| 1. The hexane-ethanol extract of Glycyrrhiza uralensis, which contains licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells. 2. Licoricidin inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis. 3. Licoricidin and licorisoflavan A are effective in inhibiting the growth of all three bacterial species(Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei), with minimal inhibitory concentrations in the range of 2-80 ug /ml, they have a potential for reducing bacterial volatile sulfur compounds (VSCs) production and therefore for controlling halitosis. 4. Licoricidin blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in new topically applied anti-ageing formulations. 5. Licoricidin and licorisoflavan A have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis. | |
| BCN6680 | 2,3-Dihydrohinokiflavone |
| 1. 2,3-Dihydrohinokiflavone (IC50 =1.6uM) shows strong activity against Leishmania. 2. 2,3-Dihydrohinokiflavone is a suppressor of matrix metalloproteinases (MMPs) gene expression. | |
| BCN6683 | Beta-Tocopherol |
| 1. Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women. 2. Beta-Tocopherol shows a slight time dependency inhibition on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA). | |
| BCN6684 | Khellactone |
| 1. Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. 2. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM. | |
| BCN6685 | Zanthobungeanine |
| 1. Zanthobungeanine shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell. 2. Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L. 3. Zanthobungeanine shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). | |
| BCN6688 | (Z)-3-Hydroxy-5-methoxystilbene |
| 1. 3-Hydroxy-5-methoxystilbene exhibits in vitro anti-mycobacterium activity against Mycobacterium tuberculosis H37Ra with IC50 values of 3.33 ug/mL in dormant phase and 3.33 ug/mL in active phase. | |
| BCN6689 | Sideritoflavone |
| 1. Sideritoflavone has anti-inflammatory effect , it is a selective inhibitor of lipoxygenase activity in vitro. | |
| BCN6695 | Licoisoflavone B |
| 1. Licoisoflavone B exhibits antimutagenic activity against carcinogenic N-methyl-N-nitrosourea (MNU), it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention. 2. Licoisoflavone B is an inhibitor of germ tube growth in the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, it can strongly inhibit germ tube growth at 0.63 ug/disc, and it can completely inhibit hyphal branching induced by a lupin strigolactone, orobanchyl acetate, in G. margarita at 0.16 ug/disc. 3. Licoisoflavone B exhibits inhibitory activity against the growth of Helicobacter pylori in vitro, it also shows anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. 4. Licoisoflavones A and B show inhibitory effects on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro. | |
