Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6785 | Triptinin B |
| 1. Triptinin A and triptinin B are leukotriene D4 antagonist constituents. | |
| BCN6786 | Trilepisflavan |
| 1. Trilepisflavan shows significant antimicrobial activity. | |
| BCN6790 | Dehydroglyasperin C |
| 1. Dehydroglyasperin C exhibits cancer chemopreventive potential via its inhibitory effect on TPA-induced neoplastic cell transformation and COX-2 modulation through regulation of the MKK4 and PI3K pathways. 2. Dehydroglyasperin C may inhibit microglia hyperactivation by increasing MKP-1 expression and acting as a potent anti-neurodegenerative agent. 3. Dehydroglyasperin C possesses potent antioxidant activity, suggests that it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. 4. Dehydroglyasperin C can attenuate proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. 5. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways. 6. Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. | |
| BCN6798 | Corynoxidine |
| 1. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. 2. Corynoxidine inhibits acetylcholinesterase activity in a dose-dependent manner, and the IC50 value of 89.0 microM. | |
| BCN6800 | Steviolbioside |
| 1. Steviolbioside is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside could be a potential remedy for human breast cancer. 2. Steviolbioside exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro. | |
| BCN6802 | Indole-3-glyoxylamide |
| 1. Indole-3-glyoxylamides are an attractive lead series for continuing development as potential therapeutic agents against prion disease. 2. A number of Indole-3-glyoxylamides have previously been reported as tubulin polymerization inhibitors, exert a cytotoxic effect against multiple cancer cell lines. | |
| BCN6803 | Gallocatechin gallate |
| 1. Tea catechins, mainly composed of (-)-epicatechin gallate and (-)-epigallocatechin gallate , effectively inhibit cholesterol absorption in rats. 2. Gallocatechin gallate can decrease osteoclastogenesis at 20 microM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations. 3. Gallocatechin gallate and epigallocatechin gallate may have anti-diabetic effects by increasing sensitivity of insulin, and gallocatechin gallate is more active than epigallocatechin gallate. 4. Gallocatechin gallate has anti-obesity activity, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling. 5. Gallocatechin gallate has strong antioxidative activities. | |
| BCN6804 | Homoeriodictyol |
| 1. Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. 2. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells. | |
