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Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.

Hot products from the professional high-purity natural products manufacturer

Cat.No.	Product Name
BCN6818	Licoricone
1. Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
BCN6819	Isoangustone A
1. Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. 2. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. 3. Isoangustone A inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. 4. Isoangustone A shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
BCN6821	Cirsimarin
1. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice, it could therefore be a potential candidate for the treatment of obesity. 2. Cirsimarin shows antioxidant activity.
BCN6822	Cirsiliol
1. Cirsiliol shows strong antioxidant activity. 2. Cirsiliol can inhibit TG accumulation in 3T3-L1 preadipocytes, it may have anti-obesity effects. 3. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.
BCN6823	Bonducellin
1. Bonducellin shows weak antiproliferative against A2780 human ovarian cancer cell line , with the IC50 value of 10.6 uM. 2. Bonducellin shows weak antimalarial activity against Plasmodium falciparum with the IC50 value of 26 uM. 3. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity. 4. Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12].
BCN6825	Abyssinone V
1. Abyssinone V is a protein tyrosine phosphatase-1B (PTP1B) inhibitor, it inhibited PTP1B activity, with IC50 values ranging from 14.8 +/- 1.1 to 39.7 +/- 2.5 microM.
BCC6072	7,8-Dihydroxyflavone
1. 7,8-Dihydroxyflavone(7,8-DHF) shows anti-inflammatory and anti-oxidant properties, it can be used as a potent facultative ingredient in health-beneficial agents to prevent or treat the skin aging or inflammatory skin disorders. 2. Treatment with 7,8-DHF during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-DHF may represent a possible breakthrough for Down syndrome. 3. 7,8-DHF improves mitochondrial respiration in STs from obese women, suggesting that the obese phenotype in the placenta can be rescued by TRKB activation. 4. 7,8-DHF is beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. 5. 7,8-DHF exhibits anti-melanogenic activity through inhibition of tyrosinase activity in α-MSH-stimulating condition, it also shows anticancer activity in melanoma cells via downregulation of α-MSH/cAMP/MITF pathway. 6. 7,8-DHF ameliorates motor deficits via suppressing α-synuclein expression and oxidative stress in the MPTP-induced mouse model of Parkinson's disease. 7. 7,8-DHF has an anti-obesity effect in vitro, it inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells. 8. 7,8-DHF has vasorelaxing and antihypertensive effects .
BCN6826	Sophoraisoflavone A
1. Sophoraisoflavone A is an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. 2. Sophoraisoflavone A is a potential MRP inhibitor. 3. Sophoraisoflavone A shows inhibitory effects on copper-induced protein oxidative modification of mice brain homogenate in vitro.