Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 2441 - 2448 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No. Product Name
BCC6999 D-CPP-ene
Potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
BCC7000 RJR 2429 dihydrochloride
Potent nAChR agonist that displays selectivity for <span class='symbol'>&#945;</span>4<span class='symbol'>&#946;</span>2 (K<sub>i</sub> = 1 nM) and <span class='symbol'>&#945;</span>1<span class='symbol'>&#946;&#947;&#948;</span> subtypes (EC<sub>50</sub> values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC<sub>50</sub> = 2 nM) and inhibits ion flux in thalamic neurons (IC<sub>50</sub> = 154 nM). Also putative <span class='symbol'>&#945;</span>3<span class='symbol'>&#946;</span>4 agonist that potentiates catecholamine release.
BCC7001 GR 159897
A potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist. Competes for binding of [3H]GR100679 to hNK2-transfected CHO cells with a pKi of 9.5. Inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Anxiolytic in vivo.
BCC7002 (-)-Xestospongin C
Reported inhibitor of IP<sub>3</sub>-dependent Ca<sup>2+</sup> release. Inhibits bradykinin</a>-induced Ca<sup>2+</sup> release in PC12 cells and attenuates PHP-induced IL-2 production in Jurkat T cells. Exhibits no effect on ryanodine receptor-mediated Ca<sup>2+</sup> release in PC12 cells. Does not interact with the IP<sub>3</sub> binding site. Recently shown to be an ineffective antagonist of IP<sub>3</sub>-evoked Ca<sup>2+</sup> release in IP<sub>3</sub> receptor expressing DT40 cells. Cell permeable.
BCC7003 GNTI dihydrochloride
Highly potent <span class='symbol'>&kappa;</span> opioid receptor antagonist (K<sub>i</sub> = 0.18 nM for human cloned <span class='symbol'>&kappa;</span> receptors expressed in CHO cells). Displays 208- and 799-fold selectivity over <span class='symbol'>&mu;</span> and <span class='symbol'>&delta;</span> receptors respectively. Reduces feeding behavior in rats with a much higher potency (300-30,000-fold) and a shorter duration of action than <em>nor</em>-binaltorphimine (Cat.No. 0347).
BCC7004 ARL 67156 trisodium salt
Selective NTPDase inhibitor (pIC<sub>50</sub> = 4.62 and 5.1 in human blood and rat vas deferens respectively).
BCC7005 LY 231617
Antioxidant; protects against ischemia-induced neuronal damage in rat models of global and focal cerebral ischemia. Neuroprotective in vitro and in vivo.
BCC7006 KT 5823
Selective inhibitor of protein kinase G (K<sub>i</sub> values are 0.23, 4 and &gt; 10 <span class='symbol'>&mu;</span>M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC<sub>50</sub> of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 <span class='symbol'>&mu;</span>M.