Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6943 | Taxinine J |
| 1. Taxinine J possesses inhibitory activity on heptoma cell in vitro. | |
| BCN6944 | Taxinine |
| 1. Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. | |
| BCN6945 | Taxin B |
| 1. Taxin B has toxic effects. | |
| BCN6946 | Taxezopidine L |
| 1. Taxezopidines K and taxezopidine L can markedly inhibit Ca2+-induced depolymerization of microtubules. | |
| BCN6948 | Taxcultine |
| 1. Taxcultine can actively promote tubulin assembly. | |
| BCN6949 | Taxagifine |
| 1. Taxagifine can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. 2. Taxagifine shows cytotoxic activity toward HepG2 cells. | |
| BCN6950 | Taxacin |
| 1. Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). 2. Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. | |
| BCN6953 | Tauroursodeoxycholic acid |
| 1. Tauroursodeoxycholic acid (TUDCA) may enhance the secretory capacity of cholestatic hepatocytes by stimulation of exocytosis and insertion of transport proteins into apical membranes via PKC-dependent mechanisms. 2. TUDCA acts as a chemical chaperone to enhance protein folding and ameliorate ER stress, increases insulin sensitivity, it may be an effective pharmacological approach for treating insulin resistance. 3. TUDCA has wide-range neuroprotective effects, it may provide a potentially useful treatment in patients with hemorrhagic stroke and perhaps other acute brain injuries associated with cell death by apoptosis. 4. TUDCA is a strong modulator of AbetaE22Q-triggered apoptosis, it prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells. 5. TUDCA exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. | |
