Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2473 - 2480 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC7031 | 5'-Iodoresiniferatoxin |
|
Potent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine. Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a K<sub>i</sub> of 5.8 nM.
|
|
| BCC7032 | PD 81723 |
|
Allosteric potentiator at the adenosine A1 receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A1 receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.
|
|
| BCC7033 | UBP1112 |
|
A selective group III mGlu receptor antagonist (apparent K<sub>d</sub> values are 5.1 and 488 <span class='symbol'>μ</span>M for group III and group II mGlu receptors respectively; IC<sub>50</sub> > 1 mM for group I, NMDA, AMPA and kainate receptors).
|
|
| BCC7034 | Sphingosine-1-phosphate |
|
Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.
|
|
| BCC7035 | SB 204741 |
|
Potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.
|
|
| BCC7036 | SB 228357 |
|
5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo.
|
|
| BCC7037 | SB 218795 |
|
Potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction.
|
|
| BCC7038 | Cromakalim |
|
Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.
|
|