Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2457 - 2464 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7015 | PPNDS |
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Potent and selective P2X<sub>1</sub> receptor antagonist (pK<sub>B</sub> = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y<sub>1</sub> receptors, and selective over ecto-nucleotidase, <span class='symbol'>α</span><sub>1A</sub>-adrenoceptors, A<sub>1</sub>, A<sub>2B</sub>, H<sub>1</sub> and M<sub>3</sub> receptors.
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| BCC7016 | UCL 1684 |
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Highly potent, non-peptidic blocker of the apamin-sensitive Ca<sup>2+</sup>-activated K<sup>+</sup> channel (K<sub>Ca</sub>2.1) (IC<sub>50</sub> = 3 nM in rat sympathetic neurons). Blocks hK<sub>Ca</sub>2.1 and rK<sub>Ca</sub>2.2 channels expressed in HEK 293 cells with IC<sub>50</sub> values of 762 and 364 pM respectively.
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| BCC7017 | MK 886 |
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An inhibitor of leukotriene biosynthesis (IC<sub>50</sub> = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC<sub>50</sub> = 30 nM for inhibition of [<sup>125</sup>I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR<span class='symbol'>α</span> antagonist (IC<sub>50</sub> = 0.5-1 <span class='symbol'>μ</span>M). Orally active <em>in vivo</em>.
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| BCC7018 | CP 94253 hydrochloride |
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Potent, selective 5-HT<sub>1B</sub> agonist (K<sub>i</sub> values are 89, 2, 860, 49 and 1,600 nM for 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>1C</sub>, 5-HT<sub>1D</sub> and 5-HT<sub>2</sub> receptors respectively). Centrally active upon systemic administration <em>in vivo</em>.
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| BCC7019 | GR 113808 |
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Potent, selective 5-HT<sub>4</sub> receptor antagonist (pK<sub>B</sub> = 9.43 in human colonic muscle, and K<sub>d</sub> = 0.15 nM for binding to cloned human 5-HT<sub>4</sub> receptors). Displays > 300-fold selectivity over 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>2A</sub>, 5-HT<sub>2C</sub> and 5-HT<sub>3</sub> receptors.
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| BCC7020 | Butabindide oxalate |
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Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (K<sub>i</sub> = 7 nM). Active <em>in vivo</em> (ID<sub>50</sub> = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).
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| BCC7021 | RX 821002 hydrochloride |
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Potent, selective <span class='symbol'>α</span><sub>2</sub>-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the <span class='symbol'>α</span><sub>2D</sub> over the <span class='symbol'>α</span><sub>2A</sub> subtypes (pK<sub>d</sub> values are 9.7 and 8.2 respectively).
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| BCC7022 | BADGE |
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PPAR<span class='symbol'>γ</span> pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPAR<span class='symbol'>δ</span> and PPAR<span class='symbol'>α</span>. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPAR<span class='symbol'>γ</span>. Acts as a PPAR<span class='symbol'>γ</span> agonist in an ECV304 cell line. Also produces PPAR<span class='symbol'>γ</span>-independent apoptosis of tumor cells via several mechanisms. Active <em>in vivo</em>.
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