Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN6969 | Stachybotramide |
| 1. Stachybotramide preferentially stimulate the plasma cholesteryl ester transfer protein (CETP)-mediated transfer of cholesteryl esters (CE) from high density lipoprotein (HDL) to both very low density lipoprotein (VLDL) and low density lipoprotein (LDL). | |
| BCN6978 | Sorokinianin |
| 1. Sorokinianin is a phytotoxin. 2. Sorokinianin has antifungal activity, it is highly effective in suppressing spore germination of F. solani (75%) at 100 ug/ml concentration. | |
| BCN6981 | Sodium cholate |
| 1. Sodium cholate (Cholic acid) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. | |
| BCN6982 | Siegeskaurolic acid |
| 1. Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation. | |
| BCN6983 | Shizukaol B |
| 1. Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway. 2. Shizukaol B shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. 3. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. 4. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha. | |
| BCN6985 | Serrin A |
| 1. Serrin A shows weak to moderate cytotoxic activities (IC50<10 uM) against two human cancer cell lines. | |
| BCN6988 | Securinine |
| 1. Securinine induces apoptosis in human leukemia HL-60 cells. 2. Securinine is a promising new monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML) . 3. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. 4. Securinine shows antifungal activity against some plant pathogenic fungi. | |
| BCN6993 | Rutaevin |
| 1. Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent. | |
