Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7087 | Cynatratoside A |
| 1. Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis. | |
| BCN7088 | Ergosta-7,22-dien-3-one |
| 1. Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of TLRs, cytokines, chemokines, and cellular adhesion molecules in J774A.1 cells. | |
| BCC7497 | α-Estradiol |
| 1. 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice, they may help to develop safe and effective therapeutics to treat Alzheimer disease. 2. 17Alpha-estradiol arrests cell cycle progression at G2/M and induces apoptotic cell death in human acute leukemia Jurkat T cells. 3. 17Alpha-estradiol is neuroprotective in male and female rats in a model of early brain injury. 4. 17Alpha-estradiol is a potent estrogen and carcinogen during development. 5. 17Alpha-estradiol induces aromatase activity in isolated human hair follicles, it may be used for topical treatment of androgenetic alopecia (AGA) in women. | |
| BCN7091 | (+)-Rhododendrol |
| 1. (+)-Rhododendrol shows anti-inflammatory effects, it can suppress the NO production by activated macrophages in vivo. | |
| BCN7092 | 1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one |
| 1. (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one shows growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes, with the IC(50) value in the range of 1-3 microg/mL. | |
| BCN7093 | 2,3-Dihydro-3alpha-methoxynimbolide |
| 1. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line. | |
| BCN7095 | 1beta-Hydroxytorilin |
| 1. 1beta-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. | |
| BCN7100 | Pterosin B |
| 1. Pterosin B is a salt-inducible kinase 3 (Sik3) pathway inhibitor, it prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. 2. Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling. 3. Pterosin B shows cytotoxicity against HL 60 cells (human leukemia) with the IC(50) value of 8.7 microg/mL. | |
