Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7147 | Alternariol |
| 1. Alternariol, a mycotoxin, is found in food and beverages infected by Alternaria alternata, it shows estrogenic potential, inhibition of cell proliferation and clastogenicity in Ishikawa and V79 cells in vitro. 2. Alternariol possesses genotoxic properties, it is a poison of topoisomerase I and II with a certain selectivity for the II isoform. 3. Alternariol has strong activities against KB and KBv200 cells with IC 50 values of 3.17, 3.12 ug/mL. 4. Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages. 5. Alternariol is a new phototoxic, DNA-intercalating agent and is a DNA cross-linking mycotoxin in near UV light. | |
| BCN7148 | Diisobutyl phthalate |
| 1. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. 2. Diisobutyl phthalate administered by gavage is embryotoxic and teratogenic, and affects the developing male reproductive tract, at maternal toxic doses. 3. Diisobutyl phthalate could through blood-brain barrier after oral intake, and disordered the way of apoptosis of hippocampal cells, and morphologic change of mitochondria mybe is the main reason of changes of neuron apoptosis. 4. Diisobutyl phthalate induced oxidative stress, which can decrease the activities of antioxidative enzymes and result in oxidative damage of tissues. | |
| BCN7150 | Negundonorin A |
| 1. Negundonorin A is strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 ug/mL. | |
| BCN7154 | Rubicordifolin |
| 1. Rubicordifolin exhibits potent cytotoxic and antitumor activities. | |
| BCN7163 | Antiquorin |
| 1. Antiquorin exhibits moderate cytotoxic activities against the human lung cancer 95-D cell line with the IC50 value of 34.5 uM. | |
| BCN7164 | 3-Methoxymollugin |
| 1. 3-Methoxymollugin is a cytotoxic compound. | |
| BCN7166 | Isoacetovanillone |
| Isoacetovanillone shows anti-inflammatory potential. | |
| BCN7168 | 2',3'-Dihydroxy-4'-methoxyacetophenone |
| 1. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease. | |
