Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN7259 | Protosappanin A |
| 1. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. 2. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. 3. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM. 4. Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway. 5. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. | |
| BCN7261 | Alterlactone |
| 1. Alterlactone shows strong radical scavenging activity. | |
| BCN7262 | 14-Norpseurotin A |
| 1. 14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. 2. 14-Norpseurotin A can significantly induce neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration. 3. 14-Norpseurotin A displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , respectively. | |
| BCN7264 | Germanicol acetate |
| 1. Germanicol acetate shows some slight cytotoxic activity against Jurkat cells . | |
| BCN7267 | Otophylloside B |
| 1. Otophylloside B shows anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. 2. Otophylloside B protects against Aβ toxicity in caenorhabditis elegans models of Alzheimer's disease. 3. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. | |
| BCN7271 | Icariside B1 |
| 1. Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells. | |
| BCN6396 | FD-838 |
| 1. FD-838 can significantly inhibit the growth of two plant fungal pathogens Botrytis cinerea and Glomerella cingulata with an minimum inhibitory concentration of 6.25 uM for each, similar to that of the positive fungicide, carbendazim. 2. FD-838 shows good antileishmanial and moderate anticancer activities, it can moderately inhibit the growth of cultured P388 and HL-60 cell lines. | |
| BCN7276 | 7-O-Methylrosmanol |
| 1. 7-O-methylrosmanol can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity. | |
