Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4145 | Deoxycalyciphylline B |
| 1. Deoxycalyciphylline B exhibits hepatic toxicity. 2. Deoxycalyciphylline B and Methyl homosecodaphniphyllate show different inhibitory effects on thephenoloxidase (PO) of Spodoptera exigua (Hbner) and the inhibitor concentrations leading to 50% (IC50) activity lost are estimated to be 2.439 mmol·L-1 for deoxycalyciphyllineB and 0.879mmol·L-1 for methyl homosecodaphniphyllate,respectively. | |
| BCN4147 | 4-Hydroxybenzamide |
| 4-Hydroxybenzamide is a natural product from Berberis pruinosa. | |
| BCN4149 | Helichrysetin |
| 1. Helichrysetin has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29, suggests that it has great potentials for development as an anticancer agent. 2. Helichrysetin has mild anti-HIV-1 PR activity. | |
| BCN4151 | epsilon-Viniferin |
| 1. Epsilon-viniferin shows a human cytochrome P450 enzymes inhition activity. 2. Epsilon-Viniferin is a bacteriostatic stilbenoid as it antagonized the bactericidal activity of vancomycin. 3. Epsilon-viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation but might protect from cell degenerescence. 4. Epsilon-viniferin exhibits good antioxidant capacity in the DMSO/O(-)(2) polar system (IC50= 0.14 mM). 5. (-)-Trans-epsilon-viniferin is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity, it may be of value as a structural template for the design and development of new antidepressant drugs. | |
| BCN4152 | alpha-Viniferin |
| Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities. Alpha-Viniferin inhibits AChE activity is specific, reversible and noncompetitive, in a dose-dependent manner, and the IC50 values of alpha-Viniferin were 2.0 microM. Alpha-Viniferin exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 microM, it down-regulates STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. | |
| BCN4154 | 4-Hydroxybenzyl alcohol |
| 4-Hydroxybenzyl alcohol possesses anti-angiogenic, anti-inflammatory and anti- nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines. It exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. | |
| BCN4158 | Alboctalol |
| 1. Alboctalol inhibits mushroom tyrosinase activity. | |
| BCN4159 | Cinnzeylanol |
| 1. Cinnzeylanol and Cinnzeylanine can kill larvae of silkworm, Bombyx mori L. at a dose of 16 ppm and inhibit larval ecdysis at 2~4 ppm. | |
