Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2665 - 2672 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7227 | ZK 93423 hydrochloride |
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Potent benzodiazepine receptor agonist (IC<sub>50</sub> = 1 nM). Non-selective between <span class='symbol'>α</span>1-, <span class='symbol'>α</span>2-, <span class='symbol'>α</span>3- and <span class='symbol'>α</span>5-subunit containing GABA<sub>A</sub> receptors (K<sub>i</sub> values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [<sup>3</sup>H]Ro15-1788 binding to human recombinant <span class='symbol'>α</span>1<span class='symbol'>β</span>3<span class='symbol'>γ</span>2, <span class='symbol'>α</span>2<span class='symbol'>β</span>3<span class='symbol'>γ</span>2, <span class='symbol'>α</span>3<span class='symbol'>β</span>3<span class='symbol'>γ</span>2 and <span class='symbol'>α</span>5<span class='symbol'>β</span>3<span class='symbol'>γ</span>2 receptors respectively). Anxiolytic following systemic administration <em>in vivo</em>.
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| BCC7228 | Ro 19-4603 |
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Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
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| BCC7229 | ZK 93426 hydrochloride |
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Potent, selective and competitive benzodiazepine receptor antagonist (IC<sub>50</sub> values are 0.4 and 0.7 nM for inhibition of [<sup>3</sup>H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar <em>in vivo</em> profile to flumazenil (Ro 15-1788); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
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| BCC7230 | Ro 15-4513 |
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High affinity benzodiazepine ligand. K<sub>i</sub> values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS <span class='symbol'>α</span>1-, <span class='symbol'>α</span>2-, <span class='symbol'>α</span>3- and <span class='symbol'>α</span>5-GABA<sub>A</sub> receptors. Displays partial agonism at DI <span class='symbol'>α</span>4- and <span class='symbol'>α</span>6-GABA<sub>A</sub> receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
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| BCC7231 | Linopirdine dihydrochloride |
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Blocker of K<sub>V</sub>7 (KCNQ) voltage-gated potassium channels; blocks K<sub>V</sub>7.1+7.3 (KCNQ2+3) / M-currents (IC<sub>50</sub> = 4 - 7 <span class='symbol'>μ</span>M) and K<sub>V</sub>7.1 (KCNQ1) homomeric channels (IC<sub>50</sub> = 8.9 <span class='symbol'>μ</span>M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration <em>in vivo</em>.
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| BCC7232 | XE 991 dihydrochloride |
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Potent and selective blocker of K<sub>V</sub>7 (KCNQ) voltage-gated potassium channels. Blocks K<sub>V</sub>7.2+7.3 (KCNQ2+3) / M-currents (IC<sub>50</sub> = 0.6 - 0.98 <span class='symbol'>μ</span>M) and K<sub>V</sub>7.1 (KCNQ1) homomeric channels (IC<sub>50</sub> = 0.75 <span class='symbol'>μ</span>M) but is less potent against K<sub>V</sub>7.1/minK channels (IC<sub>50</sub> = 11.1 <span class='symbol'>μ</span>M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration <em>in vivo</em>.
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| BCC7233 | GS 39783 |
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Positive allosteric modulator of GABA<sub>B</sub> receptor function. Potentiates the effects of GABA on [<sup>35</sup>S]GTP<span class='symbol'>γ</span>S binding at recombinant and native GABA<sub>B</sub> receptors (EC<sub>50</sub> values are 2.1 and 3.1<span class='symbol'>μ</span>M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
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| BCC7234 | Ro 04-5595 hydrochloride |
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Selective antagonist for GluN2B (formally NR2B) containing NMDA receptors (Ki = 31 nM).
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