Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2721 - 2728 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7284 | PD 160170 |
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Potent, selective non-peptidic neuropeptide Y<sub>1</sub> receptor antagonist (K<sub>i</sub> = 48 nM); selective over Y<sub>2</sub> and Y<sub>5</sub> receptors (K<sub>i</sub> > 10 <span class='symbol'>μ</span>M). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC<sub>50</sub> = 8.2 nM).
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| BCC7285 | PNU 22394 hydrochloride |
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Potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.
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| BCC7286 | Zatebradine hydrochloride |
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Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current I<sub>f</sub> (HCN channel) in sinoatrial node cells (EC<sub>50</sub> = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC<sub>50</sub> of 13.4 <span class='symbol'>μ</span>M).
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| BCC7287 | PALDA |
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Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB<sub>1</sub> receptors (at concentrations up to 5 <span class='symbol'>μ</span>M) and does not inhibit AMT or FAAH (IC<sub>50</sub> > 25 <span class='symbol'>μ</span>M). However, potentiates TRPV1-mediated effects of NADA; lowers EC<sub>50</sub> from ~ 90 to ~ 30 nM.
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| BCC7288 | STEARDA |
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Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB<sub>1</sub> receptors (at concentrations up to 5 <span class='symbol'>μ</span>M) and does not inhibit AMT or FAAH (IC<sub>50</sub> > 25 <span class='symbol'>μ</span>M). However, potentiates TRPV1-mediated effects of NADA <em>in vitro</em> and <em>in vivo</em>; enhances effects on intracellular Ca<sup>2+</sup> (EC<sub>50</sub> lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC<sub>50</sub> = 16 nM).
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| BCC7289 | 2-Palmitoylglycerol |
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Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol. Does not bind to CB<sub>1</sub> or CB<sub>2</sub> cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances <em>in vivo</em> cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
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| BCC7290 | LY 255283 |
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Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..
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| BCC7291 | Carcinine ditrifluoroacetate |
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Highly selective H<sub>3</sub> receptor antagonist (K<sub>i</sub> values are 0.30, 365 and 3621 <span class='symbol'>μ</span>M for H<sub>3</sub>, H<sub>2</sub> and H<sub>1</sub> receptors respectively). Acts as a natural antioxidant with hydroxyl radical scavenging and lipid peroxidase activities.
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