Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2737 - 2744 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7300 | GW 583340 dihydrochloride |
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Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC<sub>50</sub> values are 0.01 and 0.014 <span class='symbol'>μ</span>M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC<sub>50</sub> values are 0.11 <span class='symbol'>μ</span>M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 <span class='symbol'>μ</span>M for inhibition of non-tumor cell line HFF). Inhibits tumor growth <em>in vivo</em> by ~ 80% in a murine xenograft model following oral administration.
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| BCC7301 | DMAB-anabaseine dihydrochloride |
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Partial agonist at <span class='symbol'>α</span>7-containing neuronal nicotinic receptors and antagonist at <span class='symbol'>α</span>4<span class='symbol'>β</span>2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
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| BCC7302 | ACDPP hydrochloride |
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Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.
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| BCC7303 | CGS 9343B |
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Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC<sub>50</sub> of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na<sup>+</sup>, Ca<sup>2+</sup> and K<sup>+</sup> currents in PC12 cells and inhibits nAChR.
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| BCC7304 | [Des-octanoyl]-Ghrelin (human) |
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Non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.
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| BCC7305 | L-692,585 |
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Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (K<sub>i</sub> = 0.8 nM). Increases plasma GH levels <em>in vivo</em> and is 2- to 2.5-fold more potent than GHRP-6.
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| BCC7306 | SCH 58261 |
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Potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
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| BCC7307 | Ro 08-2750 |
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Non-peptide inhibitor of NGF that binds the NGF dimer (K<sub>D</sub> ~ 1 <span class='symbol'>μ</span>M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75<sup>NTR</sup> at submicromolar concentrations, and to both p75<sup>NTR</sup> and TrkA at concentrations > 5 <span class='symbol'>μ</span>M. Prevents NGF-induced apoptosis in SK-N-MC cells.
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