Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2761 - 2768 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7324 | SR 49059 |
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Potent and selective non-peptide vasopressin V<sub>1A</sub> receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (K<sub>i</sub> = 1.6 nM) and human (K<sub>i</sub> = 1.1 - 6.3 nM) V<sub>1A</sub> receptors. Potently antagonizes arginine vasopressin-induced effects <em>in vitro</em> (IC<sub>50</sub> = 3.7 nM for inhibition of human platelet aggregation) and is orally active <em>in vivo</em>.
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| BCC7325 | L-168,049 |
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Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC<sub>50</sub> = 3.7 nM), and moderate affinity to murine and canine GRs (IC<sub>50</sub> values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC<sub>50</sub> > 1 <span class='symbol'>μ</span>M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC<sub>50</sub> = 41 nM), and in murine liver membranes. Orally active <em>in vivo</em>.
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| BCC7326 | QX 314 chloride |
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Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.
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| BCC7327 | LOE 908 hydrochloride |
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Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
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| BCC7328 | Immethridine dihydrobromide |
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Potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM..
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| BCC7329 | AMG 9810 |
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Potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. Displays antihyperalgesic properties in a rat model of inflammatory pain.
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| BCC7330 | Ro 10-5824 dihydrochloride |
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Selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
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| BCC7331 | DMP 543 |
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K<sup>+</sup> channel blocker and acetylcholine release stimulator. Potently enhances K<sup>+</sup>-stimulated [<sup>3</sup>H]-ACh release from rat hippocampal slices (EC<sub>50</sub> = 700 nM), and also increases release of dopamine and glutamate (EC<sub>50</sub> values are 0.25 and 0.22 <span class='symbol'>μ</span>M, respectively). Orally active <em>in vivo</em>; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine both <em>in vitro</em> and <em>in vivo</em>.
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