Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4397 | Chinensine B |
| 1. Chinensine B and Chinensines A, C, D and Ε are antitumor diterpenoids. | |
| BCN4399 | Norviburtinal |
| 1. Norviburtinal possesses novel angiogenesis effect. 2. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines. 3. Norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity. | |
| BCN4400 | 2-Methoxystypandrone |
| 1. 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model. 2. 2-Methoxystypandrone specifically inhibits JAK and IKKβ kinase activities. 3. 2-Methoxystypandrone blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 4. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins. 5. 2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption. | |
| BCN4404 | Trichorabdal A |
| 1. Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori. | |
| BCN4405 | Eupatorin |
| Eupatorin has antiproliferative and antiangiogenic effects, it emerges as a promising agent in anticancer research.Eupatorin-induced cell death is mediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation. Eupatorin also has meaningful anti-inflammatory property which may be utilized in the development of novel anti-inflammatory treatments. | |
| BCN4406 | Curculigoside |
| Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. | |
| BCN4410 | alpha-Amyrin acetate |
| 1. Alpha-Amyrin acetate has anti-inflammatory activity. 2. Alpha-Amyrin acetate has antispasmodic profile and the relaxant effects. 3. Alpha-Amyrin acetate can decrease blood engorgement time and feeding rate and decline fecundity which reduce the overall survival and reproductive capacity of the malaria vector A. stephensi. 4. The oral administration of alpha-Amyrin acetate can significantly improve the diabetic condition in streptozotocin-induced diabetic rats and in diabetic db/db mice at 50 mg kg(-1) dose level. | |
| BCN4412 | N-Methylcalycinine |
| 1. N-Methylcalycinine exhibits potent AChE inhibitory activity. | |
