Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2793 - 2800 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7357 | GT 2016 |
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High affinity H<sub>3</sub> receptor antagonist (K<sub>i</sub> = 43.8 nM). Displays selectivity against H<sub>1</sub> and H<sub>2</sub> receptors (IC<sub>50</sub> >10 <span class='symbol'>μ</span>M). Increases the release of histamine in the cerebral cortex. Displays no activity at histamine methyltransferase <em>in vitro</em> at concentrations up to 3 <span class='symbol'>μ</span>M. Brain penetrant.
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| BCC7358 | [Pyr1]-Apelin-13 |
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Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
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| BCC7359 | AC 55649 |
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Potent, isoform-selective RAR<span class='symbol'>β</span>2 receptor agonist (pEC<sub>50</sub> values are 6.9, 5.7 and 5.6 at RAR<span class='symbol'>β</span>2, RAR<span class='symbol'>β</span>1 and RAR<span class='symbol'>α</span> respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
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| BCC7360 | TMPH hydrochloride |
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Potent non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). Produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant <span class='symbol'>α</span> and <span class='symbol'>β</span> subunits (i.e. <span class='symbol'>α</span>3, <span class='symbol'>α</span>4 and <span class='symbol'>β</span>2, <span class='symbol'>β</span>4 respectively). Displays little inhibition of muscle-type (<span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span><span class='symbol'>δ</span>) or <span class='symbol'>α</span>7 receptors.
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| BCC7361 | NNC 26-9100 |
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Somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).
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| BCC7362 | JNJ 10191584 maleate |
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Highly selective histamine H<sub>4</sub> receptor silent antagonist; binds with high affinity to the human H<sub>4</sub> receptor (K<sub>i</sub> = 26 nM). > 540-fold selective over the H<sub>3</sub> receptor (K<sub>i</sub> = 14.1 <span class='symbol'>μ</span>M). Inhibits mast cell and eosinophil chemotaxis <em>in vitro</em> with IC<sub>50</sub> values of 138 and 530 nM respectively. Orally active <em>in vivo</em>.
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| BCC7363 | CGP 53353 |
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Selective inhibitor of PKC<span class='symbol'>β</span>II (IC<sub>50</sub> values are 0.41 and 3.8 <span class='symbol'>μ</span>M for PKC<span class='symbol'>β</span>II and PKC<span class='symbol'>β</span>I respectively). Also inhibits prionogenic Sup35 fibrillization (IC<sub>50</sub> ~ 3.4 <span class='symbol'>μ</span>M) and inhibits <em>de novo</em> A<span class='symbol'>β</span>42 assembly <em>in vitro</em>.
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| BCC7364 | (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 |
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Potent and selective somatostatin sst<sub>2</sub> receptor agonist (K<sub>i</sub> values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst<sub>2</sub>, sst<sub>1</sub>, sst<sub>4</sub>, sst<sub>3</sub> and sst<sub>5</sub> receptors respectively).
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