Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4480 | Karavilagenin D |
| 1. Karavilagenin D exhibits inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as a promoter. 2. Karavilagenin D exhibits inhibition effect against human cancer cell lines. | |
| BCN4483 | Jangomolide |
| 1. Jangomolide, a novel limonoid from flacourtia jangomas. | |
| BCN4487 | Methyl 3-indolecarboxylate |
| Methyl 3-indolecarboxylate is a natural product fom Heracleum candicans. | |
| BCN4488 | Nemoralisin |
| 1. Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines. | |
| BCN4489 | Walsuronoid B |
| 1. Walsuronoid B shows weak antimalarial activity. | |
| BCN4490 | 1,5,15-Tri-O-methylmorindol |
| 1. 1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA. | |
| BCN4494 | Sappanchalcone |
| 1. Sappanchalcone has cytoprotective effect. 2. Sappanchalcone blocks cell cycle progression in the G2/M phase, brazilin inhibited TNFα/NF-κB signaling. 3. Sappanchalcone has anti-inflammatory effect, could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis. 4. Sappanchalcone suppresses oral cancer cell growth and induces apoptosis through the activation of p53-dependent mitochondrial, p38, ERK, JNK, and NF-κB signaling, could potentially used to treat periodontal, pulpal , periapical inflammatory lesion and oral cancer. 5. Sappanchalcone possesses the most potent effect against allergic reaction in basophilic leukemic (RBL-2H3) cells with an inhibitory concentration (IC50) value of 7.6 uM, it may have anti-allergic activity. 6. Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. | |
| BCN4496 | Dimethylmatairesinol |
| 1. Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. 2. Dimethylmatairesinol exhibits significant cytotoxicity against three human tumor cells(A-549 lung carcinoma, MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma ). | |
