Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2833 - 2840 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7397 | Ganaxolone |
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Potent positive allosteric modulator of GABA<sub>A</sub> receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA<sub>A</sub> receptors (EC<sub>50</sub> values are 94, 122 and 213 nM for <span class='symbol'>α</span>2<span class='symbol'>β</span>1<span class='symbol'>γ</span>2<sub>L</sub>, <span class='symbol'>α</span>3<span class='symbol'>β</span>1<span class='symbol'>γ</span>2<sub>L</sub> and <span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span>2<sub>L</sub> receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
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| BCC7398 | DPO-1 |
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Blocker of I<sub>Kur</sub> ultrarapid delayed rectifier potassium current and K<sub>V</sub>1.5 channels (IC<sub>50</sub> = 0.31 <span class='symbol'>μ</span>M for rK<sub>V</sub>1.5). Displays selectivity for inhibition of I<sub>Kur</sub> over I<sub>to</sub> (8-fold), I<sub>K1</sub>, I<sub>Kr</sub> and I<sub>Ks</sub> (20-fold) in native myocytes and selectivity for rat recombinant K<sub>V</sub>1.5 over K<sub>V</sub>3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
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| BCC7399 | LP 44 |
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High affinity 5-HT<sub>7</sub> receptor agonist (K<sub>i</sub> = 0.22 nM) that displays selectivity over 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC<sub>50</sub> = 2.56 <span class='symbol'>μ</span>M).
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| BCC7400 | L-BMAA hydrochloride |
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Neurotoxic glutamate agonist originally isolated from Cycas circinalis. Implicated in the pathogenesis of amyotrophic lateral sclerosis-Parkinsonism-dementia complex of Guam (Guam ALS-PD).
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| BCC7401 | Tocrifluor T1117 |
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Fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity.
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| BCC7402 | Lofepramine |
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Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.
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| BCC7403 | 6-Hydroxydopamine hydrobromide |
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Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
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| BCC7404 | NF 110 |
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High affinity P2X<sub>3</sub> receptor antagonist (K<sub>i</sub> values are 36, 82 and 4144 nM for P2X<sub>3</sub>, P2X<sub>1</sub> and P2X<sub>2</sub> recombinant receptors respectively). Shows no activity at P2Y<sub>1</sub>, P2Y<sub>2</sub> and P2Y<sub>11</sub> receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Potently inhibits <span class='symbol'>α</span>,<span class='symbol'>β</span>-meATP-evoked desensitizing currents in rat DRG neurons (IC<sub>50</sub> = 527 nM). Shows antitumor activity against several tumor types.
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