Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2857 - 2864 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7421 | TCB-2 |
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High affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.
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| BCC7422 | J 113863 |
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Potent chemokine receptor 1 (CCR1) antagonist (IC<sub>50</sub> values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC<sub>50</sub> values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. Isomer of UCB 35625.
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| BCC7423 | (±)-J 113397 |
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Potent and selective NOP receptor antagonist (IC<sub>50</sub> values are 2.3, 1400, 2200 and > 10000 nM for NOP, <span class='symbol'>κ</span>, <span class='symbol'>μ</span> and <span class='symbol'>δ</span>-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.
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| BCC7424 | OSU 6162 hydrochloride |
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Dopamine stabilizer; lacks high affinity for various neuroreceptors <em>in vitro</em> (K<sub>i</sub> values are 447 and 1305 nM for D<sub>2</sub> and D<sub>3</sub> receptors respectively and > 1 <span class='symbol'>μ</span>M for other targets). Exhibits high D<sub>2</sub> receptor occupancy <em>in vivo</em>; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.
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| BCC7425 | Cyprodime hydrochloride |
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Selective <span class='symbol'>μ</span>-opioid receptor antagonist (K<sub>i</sub> values are 5.4, 244.6 and 2187 nM for <span class='symbol'>μ</span>-, <span class='symbol'>δ</span>- and <span class='symbol'>κ</span>-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
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| BCC7426 | PD 176252 |
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Non-peptide gastrin-releasing peptide receptor (GRP-R, BB<sub>2</sub>) and neuromedin B receptor (NMB-R, BB<sub>1</sub>) antagonist (K<sub>i</sub> values are 0.17 and 1.0 nM for BB<sub>1</sub> and BB<sub>2</sub> respectively). Inhibits proliferation of rat C6 glioma cells (IC<sub>50</sub> = 2 <span class='symbol'>μ</span>M) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC<sub>50</sub> = 5 <span class='symbol'>μ</span>M).
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| BCC7427 | Milameline hydrochloride |
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Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (K<sub>i</sub> values are 2.3, 2.4, 3.6, 3.8 and 4.3 <span class='symbol'>μ</span>M for hM<sub>1</sub>, hM<sub>2</sub>, hM<sub>3</sub>, hM<sub>4</sub> and hM<sub>5</sub> receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.
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| BCC7428 | PD 198306 |
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Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC<sub>50</sub> values are > 1, > 4, > 4 and > 10 <span class='symbol'>μ</span>M for ERK, c-Src, cdks and PI 3-kinase <span class='symbol'>γ</span> respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.
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