Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4629 | Olivetol |
| Olivetol is a precursor in various syntheses of tetrahydrocannabinol. It acts as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol has antioxidant effects. | |
| BCN4630 | Butin |
| Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SOD induction via the PI3K/Akt signaling pathway.Butin against H2O2-induced apoptosis were exerted via blockade of membrane potential depolarization, inhibition of the JNK pathway and mitochondria-involved caspase-dependent apoptotic pathway, enhancing the expression of phosphorylated Akt (active form of Akt), a regulator of OGG1. | |
| BCN4631 | (E)-Aldosecologanin |
| (E)-Aldosecologanin is a natural product from Lonicera japonica. | |
| BCN4632 | Rehmannic acid |
| 1, Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. 2. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter. | |
| BCN4633 | Isopedicin |
| 1. Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE. | |
| BCN4634 | Isoscabertopin |
| 1. Isoscabertopin has anticancer activity. | |
| BCN4637 | Taxiresinol |
| 1. Taxiresinol shows notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines. 2. Taxiresinol and (7' R)-7'-hydroxylariciresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice. 3. Taxiresinol possesses significant antinociceptive activity against p -benzoquinone-induced abdominal contractions. 4. Taxiresinol shows anti-inflammatory activity, it can significantly inhibit carrageenan-induced hind paw edema in mice. 5. Taxiresinol has antiallergic activity, it show inhibitory activity on induced histamine release from the human basophilic cell line, KU812. | |
| BCN4638 | Isodeoxyelephantopin |
| 1. Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation . 2. Isodeoxyelephantopin enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kappaB-regulated gene expression. | |
