Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2937 - 2944 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7502 | IBMX |
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Phosphodiesterase inhibitor (IC<sub>50</sub> values are 13, 18, 19, 32 and 50 <span class='symbol'>μ</span>M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses <span class='symbol'>α</span>-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC<sub>50</sub> = 1.3 <span class='symbol'>μ</span>M). Facilitates differentiation of neural progenitor cells <em>in vitro</em>.
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| BCC7503 | SecinH3 |
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Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC<sub>50</sub> values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 <span class='symbol'>μ</span>M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
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| BCC7504 | PD 146176 |
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Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K<sub>i</sub> = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC<sub>50</sub> = 0.54 <span class='symbol'>μ</span>M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment <em>in vivo</em>.
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| BCC7505 | B2 |
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Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces <span class='symbol'>α</span>-synuclein-mediated toxicity.
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| BCC7506 | BYK 191023 dihydrochloride |
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Potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.
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| BCC7507 | Fumitremorgin C |
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1. Fumitremorgin C is a potent and specific chemosensitizing agent in cell lines selected for resistance to mitoxantrone that do not overexpress P-glycoprotein or multidrug resistance protein.
2. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. 3. Fumitremorgin C shows an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. 4. Fumitremorgin C shows cytotoxic activity against HCT-116 tumour cell line. |
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| BCC7508 | threo Ifenprodil hemitartrate |
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Potent <span class='symbol'>σ</span> receptor agonist (K<sub>i</sub> values are 59.1 and 2 nM for <span class='symbol'>σ</span>1 and <span class='symbol'>σ</span>2 receptors respectively) and NR2B subunit-selective NMDA receptor antagonist (IC<sub>50</sub> values are 0.22 and 324.8 <span class='symbol'>μ</span>M at NR2B and NR2A respectively). Displays ~8-fold reduced affinity at <span class='symbol'>α</span>-adrenoceptors compared to Ifenprodil. Inhibits the hERG potassium channel (IC<sub>50</sub> = 88 nM) and exhibits antiarrhythmic activity <em>in vivo</em>.
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| BCC7509 | CP 96345 |
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Potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
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