Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4790 | Furowanin A |
| 1. Furowanin A shows significant cytotoxicity against HL-60 cells. 2. Furowanin A induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis. | |
| BCN4791 | Neorauflavane |
| 1. Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM. 2. Neorauflavane can efficiently reduce melanin content in B16 melanoma cells with 12.95 uM of IC50. | |
| BCN4794 | Wittifuran X |
| 1.Wittifuran X has antioxidant and anti-inflammatory activities. | |
| BCN4795 | 4-Hydroxyphenylacetic acid |
| 4-Hydroxyphenylacetic acid has anti-inflammatory activity,it attenuates inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. 4-Hydroxyphenylacetic acid is active against the root-lesion nematode, Pratylenchus penetrans, and the pine wood nematode. | |
| BCN4796 | 14-Deoxycoleon U |
| 1. 14-Deoxycoleon U has anti-termitic activity. 2. 14-Deoxycoleon U is highly active against both wood-decay fungi. 3. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Micrococcus luteus. | |
| BCN4801 | Dalbergioidin |
| 1. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. 2. Dalbergioidin shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. 3. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. 4. Dalbergioidin ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. | |
| BCN4804 | Deguelin |
| 1. Deguelin has anti-cancer activity, such as anti osteosarcoma, lung cancer; via inducing the apoptosis of cancer cells through a ROS driven Akt pathway, EPC suppression by FAK-integrin-ILK-dependent actin remodeling . 2. Deguelin possesses antitumor effect by targeting Akt in dual axis such as EGFR and IGF1R signaling pathways and suggests that it provides an applicable therapeutic strategy for HNSCC patients. 3. Deguelin is a potent in vitro inhibitor of the mutant form of NPM1, which provides the molecular basis for its anti-leukemia activities in NPM1 mutant acute myeloid leukemia cells. | |
| BCN4805 | 6,8-Diprenylgenistein |
| 1. 6,8-Diprenylgenistein has antimicrobial activity . 2. 6,8-Diprenylgenistein has anti-bacteria activity against Gram-negative and Gram-positive bacteria. | |
