Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4734 | Annonacin |
| 1. Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines.. 2. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. 3. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases. | |
| BCN4737 | Diacetylpiptocarphol |
| 1. Diacetylpiptocarphol shows antileishmanial activity against three stages of Leishmania infantum. | |
| BCN4739 | Barpisoflavone A |
| 1. Barpisoflavone A possesses moderate estrogen partial agonistic activities and moderate antioxidant activities. | |
| BCN4741 | Stilbostemin N |
| 1. Stilbostemins N may exhibit moderate antibacterial activities. | |
| BCN4742 | Tephrosin |
| 1. Tephrosin may be valuable for augmenting the therapeutic efficacy of 2-Deoxy-D-glucose(DG), DG is currently under clinical evaluation for targeting tumor cells. 2. Tephrosin has potent antitumor activity by inducing autophagy pathway, internalization and degradation of inactivated EGFR and ErbB2. 3. Tephrosin could exert antitumor effects by inducing internalization and degradation of inactivated EGFR and ErbB2 in human colon cancer cells. | |
| BCN4743 | Eriodictyol-7-O-glucoside |
| 1. Eriodictyol-7-O-glucoside and epicatechin appears to be responsible for the antioxidant activity of pistachio skin. 2. Eriodictyol-7-O-glucoside has protective effect on cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. 3. Eriodictyol-7-O-glucoside can activate Nrf2/ARE signaling, directly associated with its neuroprotection against oxidative stress-induced ischemic; suggests that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke. | |
| BCN4745 | Goniotriol |
| 1. Goniotriol exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). 2. Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). 3. Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H187, and MCF-7 with IC(50) ranging from 0.4 to 22.7 microg/mL. | |
| BCN4748 | Cedrin |
| 1. Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. | |
