TCS 2312Potent Chk1 inhibitor CAS# 838823-31-7 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 838823-31-7 | SDF | Download SDF |
| PubChem ID | 11258443 | Appearance | Powder |
| Formula | C25H24N4O2 | M.Wt | 412.48 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 20 mM in DMSO | ||
| Chemical Name | 4-[4-[5-[4-[(cyclopropylamino)methyl]anilino]-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,5-dien-1-ylidene]-3-hydroxycyclohexa-2,5-dien-1-one | ||
| SMILES | C1CC1NCC2=CC=C(C=C2)NC3=CC(=C4C=CC(=C5C=CC(=O)C=C5O)C=C4)NN3 | ||
| Standard InChIKey | BYFCMDWKTJJQGR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H24N4O2/c30-21-11-12-22(24(31)13-21)17-3-5-18(6-4-17)23-14-25(29-28-23)27-20-7-1-16(2-8-20)15-26-19-9-10-19/h1-8,11-14,19,26-29,31H,9-10,15H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and selective checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). Enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. |
TCS 2312 Dilution Calculator
TCS 2312 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4244 mL | 12.1218 mL | 24.2436 mL | 48.4872 mL | 60.609 mL |
| 5 mM | 0.4849 mL | 2.4244 mL | 4.8487 mL | 9.6974 mL | 12.1218 mL |
| 10 mM | 0.2424 mL | 1.2122 mL | 2.4244 mL | 4.8487 mL | 6.0609 mL |
| 50 mM | 0.0485 mL | 0.2424 mL | 0.4849 mL | 0.9697 mL | 1.2122 mL |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2424 mL | 0.4849 mL | 0.6061 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.[Pubmed:17887663]
J Med Chem. 2007 Nov 1;50(22):5253-6.
The cocrystal structure of a library hit was used to design a novel series of CHK1 inhibitors. The new series retained the critical hydrogen-bonding groups of the resorcinol moiety for binding but lacked the phenolic anilide moiety. The newly designed compounds exhibited similar enzymatic activity, while demonstrating increased cellular potency. Compound 10c, showing no single agent effect, potentiated the antiproliferative effect of Gemcitabine in both prostate and breast cancer cell lines.
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