WIKI4

Inhibitor of Wnt/ß-Catenin signaling and tankyrase CAS# 838818-26-1

WIKI4

Catalog No. BCC2455----Order now to get a substantial discount!

Product Name & Size Price Stock
WIKI4: 5mg $115 In Stock
WIKI4: 10mg Please Inquire In Stock
WIKI4: 20mg Please Inquire Please Inquire
WIKI4: 50mg Please Inquire Please Inquire
WIKI4: 100mg Please Inquire Please Inquire
WIKI4: 200mg Please Inquire Please Inquire
WIKI4: 500mg Please Inquire Please Inquire
WIKI4: 1000mg Please Inquire Please Inquire
Related Products
  • MK-4827

    Catalog No.:BCC1761
    CAS No.:1038915-60-4
  • BMN-673 8R,9S

    Catalog No.:BCC1422
    CAS No.:1207456-00-5
  • XAV-939

    Catalog No.:BCC1120
    CAS No.:284028-89-3
  • PJ34

    Catalog No.:BCC1865
    CAS No.:344458-19-1
  • ABT-888 (Veliparib)

    Catalog No.:BCC1267
    CAS No.:912444-00-9

Quality Control of WIKI4

Number of papers citing our products

Chemical structure

WIKI4

3D structure

Chemical Properties of WIKI4

Cas No. 838818-26-1 SDF Download SDF
PubChem ID 2984337 Appearance Powder
Formula C29H23N5O3S M.Wt 521.59
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming)
Chemical Name 2-[3-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propyl]benzo[de]isoquinoline-1,3-dione
SMILES COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6
Standard InChIKey RNUXIZKXJOGYQP-UHFFFAOYSA-N
Standard InChI InChI=1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of WIKI4

DescriptionInhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.

WIKI4 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

WIKI4 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of WIKI4

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9172 mL 9.5861 mL 19.1721 mL 38.3443 mL 47.9304 mL
5 mM 0.3834 mL 1.9172 mL 3.8344 mL 7.6689 mL 9.5861 mL
10 mM 0.1917 mL 0.9586 mL 1.9172 mL 3.8344 mL 4.793 mL
50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.7669 mL 0.9586 mL
100 mM 0.0192 mL 0.0959 mL 0.1917 mL 0.3834 mL 0.4793 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on WIKI4

Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.

Featured Products
New Products
 

References on WIKI4

WIKI4, a novel inhibitor of tankyrase and Wnt/ss-catenin signaling.[Pubmed:23227175]

PLoS One. 2012;7(12):e50457.

The Wnt/ss-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ss-catenin signaling, WIKI4. WIKI4 inhibits expression of ss-catenin target genes and cellular responses to Wnt/ss-catenin signaling in cancer cell lines as well as in human embryonic stem cells. Furthermore, we demonstrate that WIKI4 mediates its effects on Wnt/ss-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ss-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors.

Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4.[Pubmed:23762361]

PLoS One. 2013 Jun 6;8(6):e65404.

Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate beta-catenin levels in many cancer cell lines and human embryonic stem cells. Here we confirm that WIKI4 is a high potency tankyrase inhibitor and that it selectively inhibits tankyrases over other ARTD enzymes tested. The binding mode of the compound to tankyrase 2 was determined by protein X-ray crystallography to 2.4 A resolution. The structure revealed a novel binding mode to the adenosine subsite of the donor NAD(+) binding groove of the catalytic domain. Our results form a structural basis for further development of potent and selective tankyrase inhibitors based on the WIKI4 scaffold.

Description

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.

Keywords:

WIKI4,838818-26-1,Natural Products,PARP, buy WIKI4 , WIKI4 supplier , purchase WIKI4 , WIKI4 cost , WIKI4 manufacturer , order WIKI4 , high purity WIKI4

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: