PARP
Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
Products for PARP
- Cat.No. Product Name Information
- BCC1267 ABT-888 (Veliparib)Potent PARP inhibitor
- BCC1422 BMN-673 8R,9SPARP inhibitor
- BCC1761 MK-4827PARP-1/-2 inhibitor,potent and selective
- BCC1865 PJ34PARP-l inhibitor
- BCC2076 Veliparib dihydrochloridePARP-1/PARP-2 inhibitor
- BCC2206 Olaparib (AZD2281, Ku-0059436)Potent PARP1/PARP2 inhibitor
- BCC2207 Rucaparib (AG-014699,PF-01367338)Potent PARP inhibitor
- BCC2208 Iniparib (BSI-201)PARP-1 inhibitor
- BCC2210 PJ34 hydrochloridePotent PARP inhibitor
- BCC2211 A-966492PARP-1/-2 inhibitor, highly potent
- BCC2212 INO-1001PARP inhibitor
- BCC2213 UPF 1069PARP-2 inhibitor
- BCC2214 AZD2461Novel PARP inhibitor
- BCC2448 4-HQNPARP inhibitor
- BCC2449 BYK 204165Selective PARP-1 inhibitor
- BCC2450 BYK 49187PARP-1 and PARP-2 inhibitor
- BCC2451 DR 2313PARP-1 and PARP-2 inhibitor
- BCC2452 EB 47Potent PARP-1 inhibitor
- BCC2453 JW 55Tankyrase inhibitor
- BCC2454 NU 1025Potent PARP inhibitor
- BCC2455 WIKI4Tankyrase inhibitor; inhibits Wnt signaling
- BCC3995 ME0328Selective PARP-3 inhibitor
- BCC4012 Rucaparib (free base)Potent PARP inhibitor
- BCC4173 MK-4827 hydrochloridePARP1/PARP2 inhibitor
- BCC4174 MK-4827 tosylatePARP1/PARP2 inhibitor
- BCC5179 MK-4827 Racemate