PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products for PARP

  1. Cat.No. Product Name Information
  2. BCC1267 ABT-888 (Veliparib)Potent PARP inhibitor
  3. BCC1422 BMN-673 8R,9SPARP inhibitor
  4. BCC1761 MK-4827PARP-1/-2 inhibitor,potent and selective
  5. BCC1865 PJ34PARP-l inhibitor
  6. BCC2076 Veliparib dihydrochloridePARP-1/PARP-2 inhibitor
  7. BCC2206 Olaparib (AZD2281, Ku-0059436)Potent PARP1/PARP2 inhibitor
  8. BCC2207 Rucaparib (AG-014699,PF-01367338)Potent PARP inhibitor
  9. BCC2208 Iniparib (BSI-201)PARP-1 inhibitor
  10. BCC2210 PJ34 hydrochloridePotent PARP inhibitor
  11. BCC2211 A-966492PARP-1/-2 inhibitor, highly potent
  12. BCC2212 INO-1001PARP inhibitor
  13. BCC2213 UPF 1069PARP-2 inhibitor
  14. BCC2214 AZD2461Novel PARP inhibitor
  15. BCC2448 4-HQNPARP inhibitor
  16. BCC2449 BYK 204165Selective PARP-1 inhibitor
  17. BCC2450 BYK 49187PARP-1 and PARP-2 inhibitor
  18. BCC2451 DR 2313PARP-1 and PARP-2 inhibitor
  19. BCC2452 EB 47Potent PARP-1 inhibitor
  20. BCC2453 JW 55Tankyrase inhibitor
  21. BCC2454 NU 1025Potent PARP inhibitor
  22. BCC2455 WIKI4Tankyrase inhibitor; inhibits Wnt signaling
  23. BCC3995 ME0328Selective PARP-3 inhibitor
  24. BCC4012 Rucaparib (free base)Potent PARP inhibitor
  25. BCC4173 MK-4827 hydrochloridePARP1/PARP2 inhibitor
  26. BCC4174 MK-4827 tosylatePARP1/PARP2 inhibitor
  27. BCC5179 MK-4827 Racemate

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