Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 2977 - 2984 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7543 | WS 12 |
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Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
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| BCC7544 | AC 45594 |
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Selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription.
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| BCC7545 | Alphaxalone |
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A neurosteroid anesthetic that directly activates and potentiates GABA<sub>A</sub> receptor-activated membrane current (I<sub>GABA</sub>). Efficacy but not potency is determined by the alpha subunit of the receptor (EC<sub>50</sub> values are 1.4, 1.8, 2.1, 2.4 and 2.5 <span class='symbol'>μ</span>M for <span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span>3, <span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span>1, <span class='symbol'>β</span>1<span class='symbol'>γ</span>1, <span class='symbol'>α</span>2<span class='symbol'>β</span>1<span class='symbol'>γ</span>2L and <span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span>2L isoforms respectively).
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| BCC7546 | Valerenic acid |
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Positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
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| BCC7547 | Sulprostone |
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Selective EP<sub>3</sub> and EP<sub>1</sub> receptor agonist (K<sub>i</sub> values are 0.6 and 21 nM respectively). Synthetic PGE<sub>2</sub> analog and allodynic agent.
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| BCC7548 | RO-3 |
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Selective homomeric P2X<sub>3</sub> and heteromeric P2X<sub>2/3</sub> receptor antagonist (pIC<sub>50</sub> values are 7.0 and 5.9 respectively) that exhibits no activity at P2X<sub>1</sub>, P2X<sub>2</sub>, P2X<sub>4</sub>, P2X<sub>5</sub> and P2X<sub>7</sub> receptors (IC<sub>50</sub> > 10 <span class='symbol'>μ</span>M). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.
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| BCC7549 | Mesopram |
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Orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-<span class='symbol'>γ</span>, TNF-<span class='symbol'>α</span>, IL-10 and iNOS <em>in vitro</em>. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis <em>in vivo</em>.
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| BCC7550 | A 841720 |
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Potent, non-competitive mGlu<sub>1</sub> receptor antagonist that displays 34-fold selectivity over mGlu<sub>5</sub> (IC<sub>50</sub> values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function.
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