Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4886 | 1,3,7-Trihydroxy-2-prenylxanthone |
| 1. 1,3,7-Trihydroxy-2-prenylxanthone shows weak antibacterial activity against the bacterium. | |
| BCN4887 | 13(18)-Oleanen-3-one |
| 1. δ-Amyrone(13(18)-Oleanen-3-one), a specific inhibitor of cyclooxygenase-2, possesses anti-inflammatory effects, which may be relevant to the regulation of COX-2. 2. δ-Amyrone has protective activity on LPS-induced endotoxic shock, which is attributed to reducing NO production and mediating the pro-inflammatory cytokines, inhibited NF-κB expression. 3. δ-Amyrone exerts its protective effect on experimental gastric ulcer by inhibiting NF-κB signaling pathways, which subsequently reduces overproduction of the inducible enzymes iNOS and suppresses the release of the inflammatory factors TNF-α, IL-6 and NO. | |
| BCN4888 | Calyxin H |
| 1. Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer. | |
| BCN4889 | Tiliroside |
| 1. Tribuloside can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect. 2. Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL . 3. Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.4. Tiliroside possesses anti-inflammatory, antioxidant, anti-complement, anti-diabetic, anticarcinogenic and hepatoprotective activities. Tiliroside enhances fatty acid oxidation via the enhancement adiponectin signaling associated with the activation of both AMP-activated protein kinase and peroxisome proliferator-activated receptor α and ameliorates obesity-induced metabolic disorders. | |
| BCN4890 | 3,4-Dimethoxyphenol |
| 3,4-Dimethoxyphenol has antimicrobial activity; it also has inhibition of melanin synthesis, it may be used as whitening agents in cosmetics. | |
| BCN4892 | (-)-Maackiain |
| (-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene. It shows significant growth inhibitory action on the growth of the human lymphoblastoid cell lines Molt and Raji, and shows a strong larvicidal effect against 4th instar larvae of Aedes aegypti(LC50=21.95±1.34ug/mL). | |
| BCN4895 | Lansiumarin C |
| 1. Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages. | |
| BCN4896 | Parthenolide |
| Parthenolide exhibits anti-cancer, anti-inflammatory, immunomodulatory, anti-Leishmania, and antimigraine effects, it inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.Parthenolide is also an inhibitor of the nuclear factor-kappaB pathway, can ameliorate cardiovascular derangement and outcome in endotoxic shock in rodents. | |
