Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3073 - 3080 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7641 | PF 750 |
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Irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC<sub>50</sub> = 16.2 nM) that displays no activity at a range of other serine hydrolases. Selectively inhibits FAAH within the central nervous system. Orally active.
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| BCC7642 | VU 0155041 sodium salt |
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Potent, positive allosteric modulator/allosteric agonist at mGlu<sub>4</sub> receptors (EC<sub>50</sub> = 798 and 693 nM at human and rat mGlu<sub>4</sub> receptors respectively). Active in <em>in vivo</em> models of Parkinson's disease following i.c.v. administration. Sodium salt of VU 0155041.
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| BCC7643 | BzATP triethylammonium salt |
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Prototypic P2X<sub>7</sub> receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC<sub>50</sub> = 0.7 <span class='symbol'>μ</span>M in HEK 293 cells; EC<sub>50</sub> values are 3.6 and 285 <span class='symbol'>μ</span>M for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X<sub>1</sub> (pEC<sub>50</sub> = 8.7) and P2Y<sub>1</sub> receptors and can be used as a photoaffinity label for ATPase.
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| BCC7644 | rac BHFF |
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Potent and selective GABA<sub>B</sub> receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity <em>in vivo</em> and is orally active.
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| BCC7645 | RS 25344 hydrochloride |
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Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC<sub>50</sub> values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa <em>in vitro</em>.
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| BCC7646 | AZ 11645373 |
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Potent and selective human P2X<sub>7</sub> antagonist (K<sub>B</sub> values are 5 - 7 and > 10,000 nM at hP2X<sub>7</sub> and rP2X<sub>7</sub> respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1<span class='symbol'>β</span> release <em>in vitro</em> (K<sub>B</sub> values are 15 and 92 nM respectively).
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| BCC7647 | ARL 17477 dihydrochloride |
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Selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC<sub>50</sub> values are 1 and 17 <span class='symbol'>μ</span>M for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.
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| BCC7648 | QS 11 |
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GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/<span class='symbol'>β</span>-catenin signaling pathway to upregulate <span class='symbol'>β</span>-catenin nuclear translocation. Also reduces <em>in vitro</em> migration of metastatic human breast cancer cells.
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