Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3105 - 3112 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7673 | Phenamil |
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TRPP3 channel inhibitor (IC<sub>50</sub> = 0.14 <span class='symbol'>μ</span>M). Also inhibits epithelial Na<sup>+</sup> channels (K<sub>d</sub> = 0.4 nM for a high affinity site on the epithelial Na<sup>+</sup> channel). Derivative of amiloride.
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| BCC7674 | Benzamil |
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Na<sup>+</sup>/Ca<sup>2+</sup> exhanger (NCX) inhibitor (IC<sub>50</sub> ~ 100 nM); TRPP3 channel blocker (IC<sub>50</sub> = 1.1 <span class='symbol'>μ</span>M for inhibition of Ca<sup>2+</sup>-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride.
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| BCC7675 | AM 1172 |
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Metabolically stable anandamide uptake inhibitor (IC<sub>50</sub> = 2.1 - 2.5 <span class='symbol'>μ</span>M) and fatty acid amide hydrolase (FAAH) inhibitor (K<sub>i</sub> = 3.18 <span class='symbol'>μ</span>M). Inhibits <em>N</em>-arachidonylethanolamine (AEA) accumulation (IC<sub>50</sub> = 24 <span class='symbol'>μ</span>M) and hydrolysis (K<sub>i</sub> = 3 <span class='symbol'>μ</span>M), and inhibits <em>N</em>-palmitoylethanolamine (PEA) hydrolysis (IC<sub>50</sub> = 36 <span class='symbol'>μ</span>M) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC<sub>50</sub> values are 189 and 271 nM at CB<sub>2</sub> and CB<sub>1</sub> receptors respectively).
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| BCC7676 | Gedunin |
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Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity <em>in vitro</em> (IC<sub>50</sub> values are 3.22, 8.84 and 16.8 <span class='symbol'>μ</span>M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against <em>P. falciparum</em> (IC<sub>50</sub> values are 0.14 and 3.1 <span class='symbol'>μ</span>M in parasite development and [<sup>3</sup>H]-hypoxanthine uptake assays respectively).
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| BCC7677 | LY 2365109 hydrochloride |
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Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC<sub>50</sub> values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.
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| BCC7678 | S 32826 |
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Inhibitor of autotaxin (IC<sub>50</sub> = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (<span class='symbol'>α</span>, <span class='symbol'>β</span> and <span class='symbol'>γ</span>). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 <span class='symbol'>μ</span>M. Inhibits LPA release from adipocytes (IC<sub>50</sub> = 90 nM).
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| BCC7679 | BMS 453 |
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Synthetic retinoid. Retinoic acid receptor <span class='symbol'>β</span> (RAR<span class='symbol'>β</span>) agonist <em>in vivo</em>; RAR<span class='symbol'>α</span> and RAR<span class='symbol'>γ</span> antagonist <em>in vitro</em>. Inhibits breast cell proliferation by inducing active transforming growth factor <span class='symbol'>β</span> (TGF<span class='symbol'>β</span>) and causes G<sub>1</sub> arrest.
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| BCC7680 | BMS 961 |
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Selective RAR<span class='symbol'>γ</span> agonist (EC<sub>50</sub> values are 30 and 1000 nM at RAR<span class='symbol'>γ</span> and RAR<span class='symbol'>β</span> respectively). Displays no activity at RAR<span class='symbol'>α</span> receptors.
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