Hot Natural Products & Bioactive Compounds

BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.

Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.

Hot Products from BioCrick

Showing 3161 - 3168 of 9359 hot products

BioCrick hot natural products and bioactive compounds
Catalog No. Product Name
BCC7729 VU 0238429
Selective positive allosteric modulator of M<sub>5</sub> receptors (EC<sub>50</sub> values are 1.16, &gt;30 and &gt;30 <span class='symbol'>&#956;</span>M at M<sub>5</sub>, M<sub>1</sub> and M<sub>3</sub> receptors respectively). Displays no activity at M<sub>2</sub> and M<sub>4</sub> receptors.
BCC7730 BPIPP
Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC<sub>50</sub> = 3.4 - 11.2 <span class='symbol'>&#956;</span>M). Inhibits GC-stimulated Cl<sup>-</sup> transport <em>in vitro</em> and suppresses toxin-induced intestinal fluid accumulation <em>in vivo</em>.
BCC7731 SX 011
Potent p38<span class='symbol'>&#945;</span> inhibitor (IC<sub>50</sub> = 9 nM). Also inhibits p38<span class='symbol'>&#946;</span> and JNK-2 (IC<sub>50</sub> values are 90 nM and 100 nM respectively). Displays no significant activity at p38<span class='symbol'>&#947;</span>, p38<span class='symbol'>&#948;</span>, ERK-2 and JNK-1.
BCC7732 A 987306
Potent histamine H<sub>4</sub> receptor antagonist (pK<sub>i</sub> values are 8.24 and 8.47 in human and rat H<sub>4</sub> receptors respectively). Displays 162-fold, 620-fold, and &gt; 1600-fold selectivity over human H<sub>3</sub>, H<sub>1</sub> and H<sub>2</sub> receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity <em>in vivo</em> (ED<sub>50</sub> = 42 <span class='symbol'>&#956;</span>mol/kg, ip).
BCC7733 Src I1
Potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC<sub>50</sub> values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC<sub>50</sub> values are 0.32 and 30 <span class='symbol'>&#956;</span>M respectively). Can be used in parallel with PP 1 and PP 2 to inhibit Src family kinases.
BCC7734 FR 171113
Protease-activated receptor 1 (PAR<sub>1</sub>) antagonist. Exhibits potent antiplatelet activity <em>in vitro</em>; inhibits thrombin TRAP-6-induced platelet aggregation (IC<sub>50</sub> = 2.5 <span class='symbol'>&#956;</span>M) with no effect on coagulation time.
BCC7735 (-)-Indolactam V
Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.
BCC7736 Pregnanolone
GABAA receptor positive allosteric modulator. Neuroactive steroid.