Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3177 - 3184 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC7745 | TMCB |
|
Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC<sub>50</sub> = 0.50 <span class='symbol'>μ</span>M for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (K<sub>i</sub> values are 0.25, 8.65, 11.90 and 15.25 <span class='symbol'>μ</span>M for CK2, PIM1, DYRK1a and HIPK2 respectively).
|
|
| BCC7746 | PF 514273 |
|
Potent and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
|
|
| BCC7747 | NPY 5RA972 |
|
Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.
|
|
| BCC7748 | DS2 |
|
Positive allosteric modulator of <span class='symbol'>δ</span>-subunit containing GABA<sub>A</sub> receptors (EC<sub>50</sub> = 142 nM for <span class='symbol'>α</span>4<span class='symbol'>β</span>3<span class='symbol'>δ</span> receptors). Displays no effects on GABA responses mediated by <span class='symbol'>α</span>4<span class='symbol'>β</span>3<span class='symbol'>γ</span>2 and <span class='symbol'>α</span>1<span class='symbol'>β</span>3<span class='symbol'>γ</span>2 receptors.
|
|
| BCC7749 | CITCO |
|
Constitutive androstane receptor (CAR) agonist (EC<sub>50</sub> = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ER<span class = 'symbol'>α</span>, ER<span class = 'symbol'>β</span>, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes <em>in vitro</em>.
|
|
| BCC7750 | SGS 518 oxalate |
|
Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.
|
|
| BCC7751 | S26948 |
|
Selective PPAR<span class='symbol'>γ</span> agonist (EC<sub>50</sub> = 8.83 nM). Drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice. Displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats.
|
|
| BCC7752 | N-Nonyldeoxynojirimycin |
|
Glucosidase inhibitor (IC<sub>50</sub> values are 0.42 and 8.4 <span class='symbol'>μ</span>M for acid <span class='symbol'>α</span>-glucosidase and <span class='symbol'>α</span>-1,6-glucosidase respectively). Inhibits liver glycogen breakdown <em>in vivo</em>. Also acts as a chemical chaperone; chaperones <span class='symbol'>β</span>-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
|
|