Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3201 - 3208 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7770 | RN 1734 |
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Selective TRPV4 antagonist (IC<sub>50</sub> values are 2.3, 3.2 and 5.9 <span class='symbol'>μ</span>M for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC<sub>50</sub> values are 2.3, >30, >30 and >100 <span class='symbol'>μ</span>M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.
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| BCC7771 | Pyr3 |
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Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca<sup>2+</sup> influx (IC<sub>50</sub> = 0.7 <span class='symbol'>μ</span>M) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.
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| BCC7772 | A 943931 dihydrochloride |
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Potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.
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| BCC7773 | SC 51089 |
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Selective EP<sub>1</sub> prostanoid receptor antagonist (K<sub>i</sub> values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 <span class='symbol'>μ</span>M for EP<sub>1</sub>, TP, EP<sub>3</sub>, EP<sub>2</sub>, EP<sub>4</sub>, FP and DP receptors respectively). Attenuates PGE<sub>2</sub>-induced neuronal cell death <em>in vitro</em> and slows tumor growth <em>in vivo</em>.
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| BCC7774 | CP 135807 |
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Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.
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| BCC7776 | TUG 424 |
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Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.
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| BCC7777 | BL 1249 |
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Putative potassium channel activator; thought to act as a K<sub>2P</sub>2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue <em>in vitro</em> and <em>in vivo</em> (EC<sub>50</sub> values are 1.26 and 21.0 <span class='symbol'>μ</span>M for cultured bladder and aortic tissues respectively).
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| BCC7778 | CD 2665 |
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Selective RAR<span class='symbol'>βγ</span> antagonist (K<sub>D</sub> values are 110, 306 and > 1000 nM for RAR<span class='symbol'>γ</span>, RAR<span class='symbol'>β</span> and RAR<span class='symbol'>α</span> respectively). Blocks retinoic acid-induced apoptosis <em>ex vivo</em>.
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