Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3153 - 3160 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7721 | FIPI |
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Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
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| BCC7722 | CYM 5442 hydrochloride |
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Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
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| BCC7723 | W146 |
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Potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.
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| BCC7724 | (5Z)-7-Oxozeaenol |
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Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-<span class='symbol'>β</span>-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC<sub>50</sub> = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-<span class='symbol'>κ</span>B (IC<sub>50</sub> = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-<span class='symbol'>α</span>-induced apoptosis <em>in vitro</em>.
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| BCC7725 | SU 3327 |
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Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC<sub>50</sub> = 0.7 <span class='symbol'>μ</span>M). Inhibits the protein-protein interaction between JNK and JIP (IC<sub>50</sub> = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
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| BCC7726 | (R)-DRF053 dihydrochloride |
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Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC<sub>50</sub> values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 <span class='symbol'>αβ</span> (IC<sub>50</sub>= 4.1 <span class='symbol'>μ</span>M). Also shown to inhibit amyloid-<span class='symbol'>β</span> production in N2A-APP<sub>695</sub> cells.
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| BCC7727 | Tramiprosate |
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Highly potent NR2B-selective NMDA receptor antagonist (K<sub>i</sub> = 0.8 nM); blocks NR2B-mediated calcium influx in Ltk cells (K<sub>i</sub> = 9.7 nM). Selective for NR2B subunit over <span class='symbol'>α</span><sub>1</sub>-adrenergic receptors and hERG channels (IC<sub>50</sub> values are 730 nM and 2900 nM respectively). Displays efficacy in the rat carrageenan-induced mechanical hyperalgesia assay.
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| BCC7728 | LY 311727 |
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Selective secreted phospholipase A<sub>2</sub> (sPLA<sub>2</sub>) inhibitor (IC<sub>50</sub> values are <1 <span class='symbol'>μ</span>M for group IIA and <50 <span class='symbol'>μ</span>M for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 <span class='symbol'>μ</span>M.
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