Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3097 - 3104 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7665 | Ellipticine |
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Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
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| BCC7666 | ATC 0065 |
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Orally active, potent and selective melanin-concentrating hormone receptor 1 (MCH<sub>1</sub>) antagonist (IC<sub>50</sub> = 15.7 nM) that displays > 96-fold selectivity over MCH<sub>2</sub>. Exhibits antidepressant and anxiolytic activity <em>in vivo</em>. Also displays affinity for 5-HT<sub>1A</sub> and 5-HT<sub>2B</sub> receptors (IC<sub>50</sub> values are 62.9 and 266 nM respectively).
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| BCC7667 | CGP 52411 |
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Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC<sub>50</sub> = 0.3 <span class='symbol'>μ</span>M <em>in vitro</em>). Also inhibits and reverses the formation of A<span class='symbol'>β</span>42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid <span class='symbol'>β</span>-peptide (1-42); reduces neurotoxicity by blocking Ca<sup>2+</sup> influx into neuronal cells.
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| BCC7668 | JNJ 17203212 |
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Reversible, competitive and potent TRPV1 antagonist (pK<sub>i</sub> values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H<sup>+</sup>-induced channel activation (pIC<sub>50</sub> values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity <em>in vivo</em>.
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| BCC7669 | WAY 200070 |
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Selective ER<span class = 'symbol'>β</span> receptor agonist that displays 68-fold selectivity over ER<span class = 'symbol'>α</span> (EC<sub>50</sub> values are 2 and 155 nM for ER<span class = 'symbol'>β</span> and ER<span class = 'symbol'>α</span> respectively). Displays antianxiolytic and antidepressive effects <em>in vivo</em>.
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| BCC7670 | TCS OX2 29 |
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Potent and selective OX<sub>2</sub> receptor antagonist (IC<sub>50</sub> = 40 nM). Displays >250-fold selectivity for OX<sub>2</sub> over OX<sub>1</sub> and a range of receptors, ion channels and transporters. Inhibits orexin A induced IP<sub>3</sub> accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX<sub>2</sub> receptor.
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| BCC7671 | Valinomycin |
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Selective K<sup>+</sup> ionophore (K<sub>0.5</sub> values are 48, 73, 75, 93 and 246 mM for K<sup>+</sup>, Rb<sup>+</sup>, Cs<sup>+</sup>, Na<sup>+</sup> and Li<sup>+</sup> respectively) that transports K<sup>+</sup> across biological and artificial lipid membranes. Inhibits Ca<sup>2+</sup>-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation <em>in vitro</em>.
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| BCC7672 | EIPA |
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TRPP3 channel inhibitor (IC<sub>50</sub> = 10.5 <span class='symbol'>μ</span>M). Inhibits the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE). Derivative of amiloride.
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