Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN4897 | Ergosterol peroxide |
| Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to induce cancer cell death.Ergosterol peroxide can ameliorate TGF-β1-induced activation of kidney fibroblasts, it has the potential to be developed as a therapeutic agent to prevent renal fibrosis. | |
| BCN4898 | Encecalin |
| 1. Encecalin and demethylencecalin are major phytotoxic compounds isolated from Helianthella quinquenervis (Hook) A Gray (Asteraceae), they inhibit photosystem II (from water to 2,5-dibromo-3-methyl-6-isopropyl-1,4 p-benzo-quinone). 2. Encecalin and eupatoriochromene retard seed germination and reduce radicle and hypocotyl growth of weed and crop plant seedlings. | |
| BCN4899 | Coniferaldehyde |
| 1. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. 2. Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni . | |
| BCN4900 | Sinapaldehyde |
| 1. Sinapaldehyde has effects against 65 strains of Candida . 2. The reaction of sinapaldehyde and methylpyranoanthocyanin can obtain a new bluish pigment. 3. Sinapaldehyde inhibits prostaglandin synthetase in a dose-dependent way, it dose-dependently inhibits ethyl phenylpropiolate-induced edema of the rat ear, and can inhibit electrically induced contractions of the guinea pig ileum in a dose-dependent way. | |
| BCN4901 | Cannabichromene |
| 1. Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1. 2. Cannabichromene exerts anti-inflammatory actions in activated macrophages with tonic CB1 cannabinoid signalling being negatively coupled to this effect and ameliorates experimental murine colitis. 3. Cannabichromene can raise the viability of neural stem progenitor cells (NSPCs), while inhibiting their differentiation into astroglia, possibly through up-regulation of ATP and adenosine signalling. | |
| BCN4903 | Norlichexanthone |
| 1. Norlichexanthone can promote the secretion and expression of adiponectin in cultured ST-13 adipocytes, it has the potential to treat and/or prevent lifestyle-related diseases, including metabolic syndrome, type 2 diabetes, atherosclerosis and cardiovascular diseases. 2. Norlichexanthone has antibacterial activity, it shows strong activity against Bacillus subtilis with IC50 in the range of 1-5uM, it also significantly inhibits the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95±1.56uM. 3. Norlichexanthone produces significant chemosuppression of parasitaemia, it has antimalarial activity. | |
| BCN4904 | Fustin |
| 1.Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. | |
| BCN4905 | Arteannuin L |
| 1. Arteannuin can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation. 2. Arteannuin has antimalarial activity. | |
