Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3049 - 3056 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCC7617 | L-838,417 |
|
Subtype-selective GABA<sub>A</sub> receptor partial agonist. Selectively binds to <span class='symbol'>α</span>1, <span class='symbol'>α</span>2, <span class='symbol'>α</span>3 and <span class='symbol'>α</span>5 subunits (K<sub>i</sub> values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at <span class='symbol'>α</span>1 (<span class='symbol'>α</span>1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity <em>in vivo</em>.
|
|
| BCC7618 | KC 12291 hydrochloride |
|
Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (I<sub>NaL</sub>) and prevents diastolic contracture in isolated atria <em>in vitro</em> (IC<sub>50</sub> values are 9.6 and 0.55 - 0.79 <span class='symbol'>μ</span>M respectively). Displays anti-ischemic, bradycardic and cardioprotective activity <em>in vivo</em>.
|
|
| BCC7619 | Ro 61-8048 |
|
Potent and competitive kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (K<sub>i</sub> = 4.8 nM, IC<sub>50</sub> = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.
|
|
| BCC7620 | SB 452533 |
|
Potent TRPV1 antagonist against capsaicin (pK<sub>b</sub> = 7.7), noxious heat and acid-mediated (pIC<sub>50</sub> = 7.0) receptor activation (pK<sub>i</sub> = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.
|
|
| BCC7621 | Thiostrepton |
|
Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
|
|
| BCC7622 | Compound 401 |
|
Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC<sub>50</sub> values are 0.28 and 5.3 <span class='symbol'>μ</span>M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC<sub>50</sub> values are all > 100 <span class='symbol'>μ</span>M). Induces apoptosis <em>in vitro</em>.
|
|
| BCC7623 | (±)-LY 395756 |
|
Selective metabotropic glutamate ligand for mGlu<sub>2 </sub>and mGlu<sub>3</sub> receptors (K<sub>i</sub> values are 0.165 <span class='symbol'>μ</span>M and 0.302 <span class='symbol'>μ</span>M respectively). Acts as an agonist at mGlu<sub>2</sub> and antagonist at mGlu<sub>3</sub>. Analog of LY 354740.
|
|
| BCC7624 | UTPγS trisodium salt |
|
Selective P2Y<sub>2</sub> and P2Y<sub>4</sub> receptor agonist. Enzymatically stable.
|
|