Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3065 - 3072 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7633 | SN 003 |
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Reversible corticotropin releasing factor receptor 1 (CRF<sub>1</sub>) antagonist (K<sub>i</sub> values are 3.4 and 7.9 nM at rat and human CRF<sub>1</sub> respectively) that displays >1000-fold selectivity over CRF<sub>2</sub> receptors. Suppresses CRF-induced ACTH release <em>in vitro</em> (IC<sub>50</sub> = 241 nM) and is brain penetrant.
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| BCC7634 | AP 18 |
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Reversible TRPA1 channel blocker (IC<sub>50</sub> values are 3.1 and 4.5 <span class='symbol'>μ</span>M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia <em>in vivo</em>. Also blocks TRPA1 pore dilation (IC<sub>50</sub> = 10.3 <span class='symbol'>μ</span>M for the inhibition of Yo-Pro uptake).
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| BCC7635 | SSR 146977 hydrochloride |
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Potent and selective NK<sub>3</sub> receptor antagonist (K<sub>i</sub> values are 0.26 and 19.3 nM in CHO cells expressing the human NK<sub>3</sub> and NK<sub>2</sub> receptor respectively). Also inhibits senktide</a>-induced inositol monophosphate formation and intracellular calcium mobilization (IC<sub>50</sub> = 10 nM).
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| BCC7636 | NGD 94-1 |
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High affinity D<sub>4</sub> receptor ligand; selective over D<sub>1</sub>, D<sub>2</sub>, D<sub>3</sub> and D<sub>5</sub> receptors. Displays antagonist activity at the human D<sub>4.2</sub> receptor (K<sub>i</sub> = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D<sub>4.4</sub> receptor in HEK 293 cells.
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| BCC7637 | CD 3254 |
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Selective RXR<span class='symbol'>α</span> agonist; exhibits no activity at RAR<span class='symbol'>α</span>, RAR<span class='symbol'>β</span> or RAR<span class='symbol'>γ</span> receptors.
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| BCC7638 | UVI 3003 |
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RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RAR<span class='symbol'>α</span> subunit within the context of the RAR-RXR heterodimer.
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| BCC7639 | SU 16f |
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Potent and selective platelet-derived growth factor receptor <span class='symbol'>β</span> (PDGFR<span class='symbol'>β</span>) inhibitor (IC<sub>50</sub> = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells <em>in vitro</em> (IC<sub>50</sub> = 0.11 <span class='symbol'>μ</span>M).
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| BCC7640 | 8-(3-Chlorostyryl)caffeine |
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Selective adenosine A<sub>2A</sub> receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (K<sub>i</sub> values are 54 and 28200 nM at rat A<sub>2A</sub> and A<sub>1</sub> receptors respectively and K<sub>i</sub> ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.
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