Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3137 - 3144 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7705 | 3-Bromocytisine |
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Potent agonist of <span class='symbol'>α</span>4<span class='symbol'>β</span>4, <span class='symbol'>α</span>4<span class='symbol'>β</span>2 and <span class='symbol'>α</span>7 nACh receptors (IC<sub>50</sub> values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity <span class='symbol'>α</span>4<span class='symbol'>β</span>2 nAChRs (EC<sub>50</sub> values are 0.008 and 0.05 <span class='symbol'>μ</span>M respectively).
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| BCC7706 | PD 173212 |
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Potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM). Displays selectivity over K+, Na+ and L-type Ca2+ channels. Prevents tonic seizures in the audiogenic seizure model in vivo.
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| BCC7707 | L189 |
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DNA ligase I, III and IV inhibitor (IC<sub>50</sub> values are 5, 9 and 5 <span class='symbol'>μ</span>M respectively) that blocks DNA binding (K<sub>i</sub> = 5 <span class='symbol'>μ</span>M for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
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| BCC7708 | LU AA33810 |
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Potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
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| BCC7709 | Margatoxin |
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Potent KV1.3 channel blocker (IC50 = 36 pM). Displays no effect at calcium-activated channels. Reduces VEGF-induced transmembrane calcium influxes and nitric oxide production in human endothelial cells.
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| BCC7710 | Kaliotoxin |
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Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activated K+ channels.
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| BCC7711 | Bretazenil |
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Partial agonist at the GABA<sub>A</sub> benzodiazepine site (EC<sub>50</sub> = 10 nM at <span class='symbol'>α</span>1<span class='symbol'>β</span>1<span class='symbol'>γ</span>2 receptors). Displays anticonvulsive activity <em>in vivo</em>.
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| BCC7712 | Z-Guggulsterone |
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Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K<sub>i</sub> values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K<sub>i</sub> = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity <em>in vivo</em>. More active isomer of guggulsterone.
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