Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3193 - 3200 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7761 | Endoxifen |
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Estrogen receptor <span class='symbol'>α</span> (ER<span class='symbol'>α</span>) ligand; potent antiestrogen. Metabolite of tamoxifen. Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.
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| BCC7762 | AS 1949490 |
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Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC<sub>50</sub> values are 0.34 <span class='symbol'>μ</span>M and 0.62 <span class='symbol'>μ</span>M for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis <em>in vitro</em> and <em>in vivo</em> and exhibits antidiabetic effects.
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| BCC7763 | SR 48692 |
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Neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively). Orally bioavailable.
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| BCC7764 | Reversan |
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Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma <em>in vivo</em>. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.
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| BCC7765 | PD 161570 |
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Selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
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| BCC7767 | Efonidipine hydrochloride monoethanolate |
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Selective blocker of L-type and T-type Ca2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.
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| BCC7768 | Stauprimide |
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Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCs <em>in vitro</em>.
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| BCC7769 | RN 1747 |
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Selective TRPV4 agonist (EC<sub>50</sub> values are 0.77, 4.0 and 4.1 <span class='symbol'>μ</span>M for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC<sub>50</sub> values are 0.77, >30, >30 and >100 <span class='symbol'>μ</span>M for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC<sub>50</sub> = 4 <span class='symbol'>μ</span>M).
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