Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3249 - 3256 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7820 | PG 01 |
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Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. Corrects gating defects of CFTR mutants such as <span class='symbol'>Δ</span>F508 (K<sub>a</sub> = 0.3 <span class='symbol'>μ</span>M), E193K and G970R (K<sub>d</sub> values are 0.22 <span class='symbol'>μ</span>M and 0.45 <span class='symbol'>μ</span>M respectively). Increases <span class='symbol'>Δ</span>F508-CFTR Cl<sup>-</sup> currents in the presence of forskolin; displays no effect on Ca<sup>2+</sup>-activated Cl<sup>-</sup> current.
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| BCC7821 | Colivelin |
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Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid <span class='symbol'>β</span>-peptide (1-43) at a concentration of 100 fM <em>in vitro</em>. Suppresses neuronal death by activating STAT3 <em>in vitro</em>; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.
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| BCC7822 | TNP |
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Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC<sub>50</sub> = 0.47 <span class='symbol'>μ</span>M for inhibition of InsP<sub>7</sub> formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC<sub>50</sub> = 10.2 <span class='symbol'>μ</span>M). Binds to the ATP binding site of IP3K (K<sub>i</sub> = 4.3 <span class='symbol'>μ</span>M).
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| BCC7823 | exo-IWR 1 |
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Negative control for <em>endo</em>-IWR 1. 25-fold less active than <em>endo</em>-IWR 1; exhibits decreased activity against the Wnt/<span class='symbol'>β</span>-catenin pathway.
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| BCC7824 | CBiPES hydrochloride |
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Selective positive allosteric modulator of the mGlu<sub>2</sub> receptor (IC<sub>50</sub> = 98.2 nM). Mimics the action of LY 379268; attenuates ketamine-evoked histamine release <em>in vivo</em>.
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| BCC7825 | trans-Ned 19 |
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Nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca<sup>2+</sup> release (IC<sub>50</sub> = 6 nM); also inhibits [<sup>32</sup>P]NAADP binding (IC<sub>50</sub> = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of <em>cis</em>-Ned 19.
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| BCC7826 | YIL 781 |
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Ghrelin receptor antagonist (GHS-R1a) (K<sub>i</sub> = 17 nM). Displays no significant affinity for the motilin receptor (K<sub>i</sub> = 6 <span class='symbol'>μ</span>M). Blocks the effects of ghrelin on insulin secretion both <em>in vivo</em> and <em>in vitro</em>. Improves glucose homeostasis <em>in vivo</em>.
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| BCC7827 | AR-R 17779 hydrochloride |
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Selective agonist of <span class='symbol'>α</span>7 nAChRs (K<sub>i</sub> values are 190 and 16000 nM for rat <span class='symbol'>α</span>7 and <span class='symbol'>α</span>4<span class='symbol'>β</span>2 receptors respectively). CNS penetrant after systemic administration.
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