Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3297 - 3304 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7868 | Bisindolylmaleimide II |
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Potent, ATP-competitive protein kinase C (PKC) inhibitor (IC<sub>50</sub> = 0.01 <span class='symbol'>μ</span>M). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC<sub>50</sub> values are 0.75 and 2<span class='symbol'>μ</span>M for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC<sub>50</sub> ~ 0.03 <span class='symbol'>μ</span>M for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).
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| BCC7869 | LY 2087101 |
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Allosteric potentiator of <span class='symbol'>α</span>7, <span class='symbol'>α</span>4<span class='symbol'>β</span>2 and <span class='symbol'>α</span>4<span class='symbol'>β</span>4 nAChRs; displays selectivity against <span class='symbol'>α</span>3<span class='symbol'>β</span>4 nAChRs. Thought to potentiate agonist-evoked <span class='symbol'>α</span>7 responses by binding within the nAChR transmembrane region.
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| BCC7870 | Phorbol 12,13-dibutyrate |
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Protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca<sup>2+</sup> concentration. Also inhibits the activity of Na<sup>+</sup>,K<sup>+</sup> ATPase in OK cells.
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| BCC7871 | Gisadenafil besylate |
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Potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.
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| BCC7872 | NS 5806 |
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K<sub>V</sub>4.3 channel activator; mediates the transient outward K<sup>+</sup> current (I<sub>to</sub>). Increases I<sub>Kv4.3</sub> peak current amplitude in CHO-K1 cells expressing K<sub>V</sub>4.3 and KChIP2 (EC<sub>50</sub> = 5.3 <span class='symbol'>μ</span>M). Inhibits K<sub>V</sub>1.4-mediated currents independently of KChIP2. Also slows the decay of K<sub>V</sub>4.2 and K<sub>V</sub>4.3 currents in the presence of KChIP2.
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| BCC7873 | PIT 1 |
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Selective PIP<sub>3</sub> antagonist. Blocks the binding of PIP<sub>3</sub> to the pleckstrin homology (PH) domain of Akt (IC<sub>50</sub> = 31.03 <span class='symbol'>μ</span>M). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP<sub>3</sub>-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity <em>in vivo</em>.
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| BCC7874 | KS 176 |
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Selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC<sub>50</sub> values are 0.59 and 1.39 <span class='symbol'>μ</span>M in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
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| BCC7875 | VU 0364739 hydrochloride |
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Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).
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