Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5302 | Cabraleone |
| 1. The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line. | |
| BCN5304 | Cryptotanshinone |
| Cryptotanshinone is a potent STAT3 inhibitor with IC50 of 4.6 μM, and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. It is also an AR inhibitor to suppress androgen/AR-mediated cell growth and PSA expression by blocking AR dimerization and the AR-coregulator complex formation. Cryptotanshinone has anti-atherosclerosis, neuroprotective, anti-cancer,and anti-neointimal formation activities. Cryptotanshinone reverses DEX-induced androgen excess and ovarian IR in mice through activation of insulin signaling and the regulation of glucose transporters and hormone-synthesizing enzymes, it has an inhibitory effect on MMP-9 production and migration of human aortic smooth muscle cells treated with TNF-alpha in a dose-dependent manner. | |
| BCN5306 | Cabraleahydroxylactone |
| 1. Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line. 2. Cabraleahydroxylactone shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL). | |
| BCN5308 | 3-Epicabraleahydroxylactone |
| 1. 3-Epicabraleahydroxylactone has anti-tumor promoting effect. 2. 3-Epicabraleahydroxylactone has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter. | |
| BCN5309 | Vestitol |
| Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemical barrier against the intrusion of the parasite. | |
| BCN5310 | Ligustroside |
| 1. Ligustroside shows little antioxidant activity. 2. Ligustroside shows moderate antiviral activities against parainfluenza type 3 virus. 3. Ligustroside has anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. | |
| BCN5312 | 3-Hydroxy-11-ursen-28,13-olide |
| 1. 3β-Hydroxy-urs-11-en-28,13β-olide exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. 2. 3β-Hydroxy-urs-11-en-13β,28-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. | |
| BCN5313 | 3-Acetoxy-11-ursen-28,13-olide |
| 1. 3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. 2. 3β-Acetoxy-urs-11-en-28,13β-olide exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |
