Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3361 - 3368 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7934 | Wiskostatin |
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Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP<sub>2</sub>-induced actin polymerization (EC<sub>50</sub> ~ 4<span class='symbol'>μ</span>M).
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| BCC7935 | 8-Chloroadenosine |
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Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
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| BCC7936 | VU 29 |
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Potent allosteric potentiator at the rat mGlu<sub>5</sub> receptor (EC<sub>50</sub> = 9 nM); binds to the MPEP allosteric site (K<sub>i app</sub> = 244 nM). Selective for mGlu5 over mGlu<sub>1</sub> and mGlu<sub>2</sub> receptors (EC<sub>50</sub> values are 557 nM and 1.51 <span class='symbol'>μ</span>M for mGlu<sub>1</sub> and mGlu<sub>2</sub> respectively). Potentiates both DHPG-induced LTP and threshold <span class='symbol'>θ</span>-burst stimulation (TBS)-induced LTP in rat hippocampal slices. Analog of CDPPB.
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| BCC7937 | 20(S)-Hydroxycholesterol |
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Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine</a> binding site. Activates Hedgehog (Hh) signaling (EC<sub>50</sub> ~ 3<span class='symbol'>μ</span>M for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).
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| BCC7938 | STF 31 |
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Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
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| BCC7939 | (R)-DPN |
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Enantiomer of DPN. Displays higher affinity for estrogen receptor (ER) <span class='symbol'>β</span> over ER<span class='symbol'>α</span> (K<sub>i</sub> values are 1.82 and 147 nM respectively).
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| BCC7940 | BC 11-38 |
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Selective phosphodiesterase (PDE) 11 inhibitor (IC<sub>50</sub> = 0.28 <span class='symbol'>μ</span>M for PDE11; IC<sub>50</sub> values are >100 <span class='symbol'>μ</span>M for PDE1 - PDE10). Significantly elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells.
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| BCC7941 | MMF |
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Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF.
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