Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3377 - 3384 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7950 | MRT 10 |
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Smoothened (Smo) receptor antagonist (IC<sub>50</sub> = 0.5 <span class='symbol'>μ</span>M in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC<sub>50</sub> = 2.5 <span class='symbol'>μ</span>M); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC<sub>50</sub> = 2.5 <span class='symbol'>μ</span>M in HEK293 cells).
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| BCC7951 | 3,5-DHBA |
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Selective agonist of hydroxycarboxylic acid receptor 1 (HCA<sub>1</sub>, also known as GPR81) (EC<sub>50</sub> ~150 <span class='symbol'>μ</span>M). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA<sub>2</sub> (at concentrations >10 mM) and no activity at HCA<sub>3</sub>, free fatty acid receptor (FFAR) 2 or FFAR3.
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| BCC7952 | Auranofin |
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Inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.
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| BCC7953 | PTIQ |
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Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
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| BCC7954 | (±)-SLV 319 |
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Potent and selective CB<sub>1</sub> receptor antagonist (K<sub>i</sub> = 7.8 nM). Exhibits 1000-fold selectivity for CB<sub>1</sub> over CB<sub>2</sub> receptors. Inhibits CP 55,940</a>-induced hypotension and WIN 55,212-2</a>-induced hypothermia <em>in vivo</em>. Orally active.
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| BCC7955 | Tegaserod maleate |
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Partial agonist of 5-HT4 (Ki = 12 nM).
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| BCC7956 | MEDICA 16 |
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Free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
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| BCC7957 | Penitrem A |
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Potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively). Displays no effect on native delayed rectifier K+ and KATP currents, or cloned KV1.5 channels. Blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo.
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