Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 3337 - 3344 of 9359 hot products
| Catalog No. | Product Name |
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| BCC7910 | TC 14012 |
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CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).
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| BCC7911 | ICA 069673 |
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Selective K<sub>V</sub>7.2/K<sub>V</sub>7.3 (KCNQ2/3) channel opener (EC<sub>50</sub> = 0.69 <span class='symbol'>μ</span>M). Exhibits 20-fold selectivity for K<sub>V</sub>7.2/K<sub>V</sub>7.3 over K<sub>V</sub>7.3/K<sub>V</sub>7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
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| BCC7912 | YC 1 |
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Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC<sub>50</sub> = 14.6 <span class='symbol'>μ</span>M); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC<sub>50</sub> = 1.9 <span class='symbol'>μ</span>M). Also displays antiproliferative activity <em>in vitro</em> and <em>in vivo</em> by inducing G<sub>1</sub> cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.
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| BCC7913 | TPEN |
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Heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Cell permeable.
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| BCC7914 | GW 542573X |
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Activator of small-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channels (K<sub>Ca</sub>2); selective for K<sub>Ca</sub>2.1 (EC<sub>50</sub> = 8.2 <span class='symbol'>μ</span>M in HEK293 cells expressing hK<sub>Ca</sub>2.1) with the profile hK<sub>Ca</sub>2.1 > hK<sub>Ca</sub>2.2 = hK<sub>Ca</sub>2.3 > hK<sub>Ca</sub>3.1 (IK).
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| BCC7915 | Nigericin sodium salt |
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Potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin. Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.
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| BCC7916 | SB 268262 |
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Selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
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| BCC7917 | FC 131 |
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CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
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